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AgelessRx vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

AgelessRx vs Signos: Overview

Choosing between AgelessRx and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

AgelessRx offers both semaglutide and tirzepatide at $99/month with a rating of 8.4/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $28/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$28/mo

Rating Difference

0.6

Winner

AgelessRx

Best For

Budget

AgelessRx

View full AgelessRx review →

Rating

8.4/10Better

Monthly Price

$99Cheaper

Medications

semaglutidetirzepatideliraglutidemetformin

Pros

✓The branded-drug pricing model is the most cost-honest we have seen: $50 + cost of medication for the Wegovy pill, and $65 + medication for Wegovy or Zepbound, with the drug supplied through the manufacturer's own direct programme rather than marked up
✓Compounded microdosing options are cheap by category standards: microdosing semaglutide from $99/month and microdosing tirzepatide from $159/month (checked July 27, 2026)
✓Metformin from $25/month for patients who do not need or want a GLP-1
✓Eligibility is framed clinically rather than universally - 'Ideal for adults with BMI >27' and 'Use with reduced-calorie meal plan and exercise for best results'
✓Efficacy figures are attached to the FDA-approved products they actually come from, such as the 14% average for the Wegovy pill, rather than being borrowed for compounded versions
✓Trustpilot rating of 4.4 across 2,407 reviews
✓Longevity-trained clinicians and a broader diagnostic offering including BioAge tests and health monitoring
✓Compounded liraglutide is offered with a specific safety warning about allergic reactions, rather than generic boilerplate

Cons

✗The core compounded offering is microdosing, which is not an evidence-based protocol. The trials behind semaglutide and tirzepatide used full therapeutic doses; there is no comparable evidence for the lower doses sold here, and AgelessRx's own wording only claims it 'may support moderate weight loss'
✗If you want the weight loss the headline GLP-1 figures describe, microdosing is unlikely to deliver it - this is positioned as longevity support, not maximal weight reduction
✗A fourth price appears at category level: the GLP-1 landing block says 'Starting at $139' while the individual products are listed at $99 and $159. That $139 matches nothing on the page
✗For the branded route you pay the monitoring fee plus the full manufacturer price, so the real monthly cost is far above the $50-65 shown and depends entirely on the drug
✗The compounded disclosure is brief - it notes the products come from a licensed compounding pharmacy but does not state plainly on the product page that they are not FDA-approved
✗No published refund or cancellation policy was found on the pages we checked
✗No customer phone number or support hours are published
✗GLP-1 sits inside a wide longevity catalogue, so the weight-management pathway competes for attention with NAD+, GSH and BioAge testing

Choose AgelessRx

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	AgelessRx	Signos
Monthly Price	$99	$127
Rating	8.4/10	7.8/10
Medications	semaglutide, tirzepatide, liraglutide, metformin	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Not published	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Clinician monitoring included in the Access & Monitoring fee	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None published	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Not published on the product pages	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose AgelessRx if you:

→Want to save $28/month with a more affordable option
→Prefer a higher-rated service (8.4/10 vs 7.8/10)
→Want more medication options to choose from
→Value: the branded-drug pricing model is the most cost-honest we have seen: $50 + cost of medication for the wegovy pill, and $65 + medication for wegovy or zepbound, with the drug supplied through the manufacturer's own direct programme rather than marked up

Get started with AgelessRx

Choose Signos if you:

→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

AgelessRx

AgelessRx website

Signos

Signos website

Our recommendation

AgelessRx comes out ahead with a higher rating of 8.4/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with AgelessRx

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