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Hello Alpha vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Hello Alpha vs Signos: Overview

Choosing between Hello Alpha and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Hello Alpha offers both semaglutide and tirzepatide at $79/month with a rating of 8.3/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $48/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$48/mo

Rating Difference

0.5

Winner

Hello Alpha

Best For

Budget

Hello Alpha

View full Hello Alpha review →

Rating

8.3/10Better

Monthly Price

$79Cheaper

Medications

semaglutidetirzepatideorforglipronmetforminbupropion

Pros

✓States explicitly that it only prescribes FDA-approved medications, so nothing here is compounded
✓The weight loss programme is $79/month, with general membership from $29/month (checked July 28, 2026)
✓It works with your insurance to find the lowest-cost medication rather than defaulting to cash-pay
✓Offers a genuine range of GLP-1 options including semaglutide, tirzepatide and the newer oral orforglipron (Foundayo), plus metformin and bupropion where appropriate
✓24/7 messaging with your provider and appointment-free online visits
✓You keep the same dedicated provider throughout rather than seeing whoever is available
✓Medications ship free if prescribed
✓Named, board-certified medical team with specialised training in women's health

Cons

✗The $79/month programme fee is separate from medication cost, so your total depends on what insurance covers
✗Women's health is the explicit focus, so it is not the right fit for men
✗General membership at $29/month and the $79 weight loss programme are different things - check which you are signing up for
✗No published phone number; contact runs through the platform
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy

Choose Hello Alpha

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Hello Alpha	Signos
Monthly Price	$79	$127
Rating	8.3/10	7.8/10
Medications	semaglutide, tirzepatide, orforglipron, metformin, bupropion	continuous glucose monitoring
Insurance Accepted	Yes	No
Support Hours	24/7 messaging with your provider	In-app dietitian chat; hours not published
Live Chat	Available	Available
Free Shipping	Yes	Yes
Shipping Speed	Medications ship free to your door, if prescribed	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Included	Included
Follow-up Frequency	Ongoing care with a consistent dedicated provider, 24/7 messaging	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None published	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Membership based; terms not published	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Hello Alpha if you:

→Want to save $48/month with a more affordable option
→Prefer a higher-rated service (8.3/10 vs 7.8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Value: states explicitly that it only prescribes fda-approved medications, so nothing here is compounded

Get started with Hello Alpha

Choose Signos if you:

→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Hello Alpha

Hello Alpha website

Signos

Signos website

Our recommendation

Hello Alpha comes out ahead with a higher rating of 8.3/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Hello Alpha

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