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EllieMD vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

EllieMD vs Signos: Overview

Choosing between EllieMD and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

EllieMD offers both semaglutide and tirzepatide at $229/month with a rating of 7.2/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $102/month is significant - Signos is the more budget-friendly option, while EllieMD positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$102/mo

Rating Difference

0.6

Winner

Signos

Best For

Budget

EllieMD

View full EllieMD review →

Rating

7.2/10

Monthly Price

$229

Medications

semaglutidetirzepatide

Pros

✓Published pricing for both microdose programmes: $229/month for the single-agonist GLP-1 ($687 total) and $239/month for the dual-agonist ($717 total)
✓No hidden membership, shipping or consultation fees, stated as a headline on the microdose page
✓Available in all 50 states
✓The partner pharmacy is named - Clover Pharmacy - and described as dispensing from 503A-compliant, state-licensed facilities
✓Payment is refunded if the medical provider determines you are not eligible for an EllieMD programme
✓24/7 access to a provider is included in the plan rather than sold as an upgrade
✓A state-licensed, board-certified MD, DO or qualified medical provider reviews your intake, and a phone call may be required rather than everything being asynchronous
✓The compounding disclaimer is explicit: compounded medications are not FDA-approved and the FDA does not review them for safety, efficacy or quality
✓It discloses that vial appearance, contents and dosage may vary based on your personalised prescription
✓Offers a paid 15-minute consultation with a wellness expert that comes with a $25 credit toward your next order

Cons

✗The whole proposition is microdosing, which has no controlled trial evidence behind it. Every published GLP-1 outcome - the 15% and 20% figures the category is built on - comes from full therapeutic doses
✗Both prices are quoted per month but billed as a multi-month total ($687 and $717), so the real commitment is three months up front
✗Compounded medication, not FDA-approved
✗The catalogue mixes prescription GLP-1s with Thymosin Alpha-1, hormone therapy, protein supplements and skincare, which blurs the line between medicine and wellness retail
✗The claim that "community support can double weight loss efficacy" is footnoted to a 2015 Northwestern citation and used to market a product that citation did not test
✗No phone number, support email or business address is published
✗No insurance billing and no HSA/FSA information
✗It is not clear from the site whether full therapeutic dosing is available at all, or only microdoses

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	EllieMD	Signos
Monthly Price	$229	$127
Rating	7.2/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Company advertises 24/7 support from doctors and specialists, included in the plan	In-app dietitian chat; hours not published
Live Chat	Available	Available
Free Shipping	Yes	Yes
Shipping Speed	Typically 2-10 business days; no shipping fees	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	24/7 direct access to a provider included in the plan	Continuous glucose data with in-app dietitian support
Money-back Guarantee	Payment refunded if the medical provider determines you are not eligible	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	A refund and returns policy is published; multi-month programmes are billed as a total	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose EllieMD if you:

→Want more medication options to choose from
→Value: published pricing for both microdose programmes: $229/month for the single-agonist glp-1 ($687 total) and $239/month for the dual-agonist ($717 total)

Get started with EllieMD

Choose Signos if you:

→Want to save $102/month with a more affordable option
→Prefer a higher-rated service (7.8/10 vs 7.2/10)
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

EllieMD

EllieMD website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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