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Enhance MD vs Sesame Care

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Enhance MD vs Sesame Care: Overview

Choosing between Enhance MD and Sesame Care for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Enhance MD offers both semaglutide and tirzepatide at $212/month with a rating of 7.7/10. Sesame Care also provides both semaglutide and tirzepatide at $59/month with a 8.7/10 rating.

The price difference of $153/month is significant - Sesame Care is the more budget-friendly option, while Enhance MD positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$153/mo

Rating Difference

1.0

Winner

Sesame Care

Best For

Budget

Enhance MD

View full Enhance MD review →

Rating

7.7/10

Monthly Price

$212

Medications

semaglutidetirzepatide

Pros

✓One price at every dose, stated as 'One consistent price from your first dose to your last', so titrating up never raises the bill
✓Full tier pricing is published: GLP-1 Core (semaglutide) $112 first month then $212/mo, Advanced (tirzepatide) $180 then $280/mo, and microdosing tirzepatide at $169/mo (checked July 27, 2026)
✓The compounded, not-FDA-approved disclosure is unambiguous and placed next to the products rather than in a footer
✓Product images are labelled 'Not actual vial - For marketing purposes only'
✓The microdosing option is framed honestly, stating it suits patients seeking longevity benefits and that 'weight loss may occur, but isn't the primary aim' rather than overselling it
✓Medication ships quarterly, so there are fewer delivery events to manage
✓Discount codes and their terms are stated plainly - $100 off 3+ month plans, $50 off monthly

Cons

✗Enhance MD sells a combined semaglutide plus tirzepatide product, marketed as 'GLP-1 Elite' at $322/month. No published clinical trial evaluates taking these two medicines together; both act on the GLP-1 receptor, so stacking them plausibly compounds gastrointestinal side effects without established additional benefit. Anyone considering it should discuss the evidence base with an independent clinician first
✗The '100% Money-back guarantee' is not a money-back guarantee. Its own wording limits it to onboarding: 'If at any point during the onboarding process your provider finds you ineligible for medication, Enhance.MD will provide a refund.' Once you are prescribed, it does not apply
✗First-month pricing nearly doubles at renewal - $112 becomes $212 for semaglutide and $180 becomes $280 for tirzepatide
✗Trustpilot carries 159 reviews against a claim of 10,000+ patients transformed
✗This offer is not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia - eleven states
✗No published customer phone number or support hours
✗No BBB profile or independent complaint record to check
✗Quarterly shipping means committing to a longer supply of a medication you may not tolerate

Choose Enhance MD

Sesame Care

View full Sesame Care review →

Rating

8.7/10Better

Monthly Price

$59Cheaper

Medications

semaglutidetirzepatideorforglipron

Pros

✓Publishes cash prices dose by dose, which no other provider on this site does. Zepbound KwikPen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
✓The same detail applies across the range: Wegovy pill $149/mo (1.5mg, 4mg) or $299 (9mg, 25mg); Wegovy pen $199 for the first two months for new patients then $349; Foundayo from $149 to $349 depending on dose (checked July 27, 2026)
✓Every medication offered is FDA-approved and branded - no compounded product is involved
✓Insurance is accepted, and with coverage medication can drop to as low as $25/mo
✓The care programme itself - video visits, dedicated provider, labs and messaging - starts at $59/mo
✓Efficacy milestones are properly sourced, citing a study of injectable semaglutide 2.4mg with the population spelled out (BMI 30+, or 27+ with a weight-related condition, non-diabetic) and paired with lifestyle change
✓A full refund is available if you cancel at least three hours before your first visit
✓The wider marketplace lets you compare individual providers on price, with appointments from $37

Cons

✗The $59/mo headline depends on a 12-month 'Success by Sesame' commitment, and the annual fee is explicitly non-refundable once paid - cancel in month two and you do not get the remaining ten months back
✗Medication costs are not included in the programme price, which Sesame states plainly but which means the real monthly outlay is the subscription plus the drug
✗Cash prices escalate steeply with dose. Zepbound more than doubles from $299 to $698 as you titrate to a maintenance dose, so the entry price is not the price you will end up paying
✗The Wegovy pen intro rate of $199 applies to new patients only and for two months, after which it is $349
✗Monthly subscribers are not refunded for months already paid, even if unused
✗Because pricing depends on insurance status, pharmacy and dose, there is no single figure you can plan around before signing up
✗This is a general healthcare marketplace, so the weight-loss programme sits alongside urgent care and prescription refills rather than being a dedicated speciality service

Choose Sesame Care

Feature-by-feature comparison

Feature	Enhance MD	Sesame Care
Monthly Price	$212	$59
Rating	7.7/10	8.7/10
Medications	semaglutide, tirzepatide	semaglutide, tirzepatide, orforglipron
Insurance Accepted	No	Yes
Support Hours	Not published	Not published
Live Chat	No	No
Free Shipping	Yes	No
Shipping Speed	Medication shipped every 12 weeks	Filled at your pharmacy; not shipped by Sesame
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Ongoing provider care and support included	Ongoing video visits, labs and messaging with a dedicated provider
Money-back Guarantee	Advertised as a 100% money-back guarantee, but it only covers being found ineligible during onboarding	Full refund if you cancel at least 3 hours before your first visit; annual fees are non-refundable once paid
Cancellation Policy	Plans run monthly or in 3+ month blocks; no separate cancellation policy published	Self-cancel monthly or annual subscriptions any time, but past months and annual fees are not refunded

Which should you choose?

Choose Enhance MD if you:

→Value: one price at every dose, stated as 'one consistent price from your first dose to your last', so titrating up never raises the bill

Get started with Enhance MD

Choose Sesame Care if you:

→Want to save $153/month with a more affordable option
→Prefer a higher-rated service (8.7/10 vs 7.7/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Want personalized coaching support included
→Value: publishes cash prices dose by dose, which no other provider on this site does. zepbound kwikpen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start

Get started with Sesame Care

Website previews

Enhance MD

Enhance MD website

Sesame Care

Sesame Care website

Our recommendation

Sesame Care comes out ahead with a higher rating of 8.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Sesame Care

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