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Foundayo vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Foundayo vs Signos: Overview

Choosing between Foundayo and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Foundayo focuses on orforglipron at $149/month with a rating of 9.2/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $22/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$22/mo

Rating Difference

1.4

Winner

Foundayo

Best For

Quality

Foundayo

View full Foundayo review →

Rating

9.2/10Better

Monthly Price

$149

Medications

orforglipron

Pros

✓The first and only FDA-approved GLP-1 pill for weight loss that can be taken at any time of day with no food or water restrictions, approved 1 April 2026
✓In the ATTAIN-1 trial, participants on the highest dose who stayed on treatment lost an average of 27.3 pounds (12.4% of body weight) against 2.2 pounds (0.9%) on placebo
✓Counting everyone randomised regardless of whether they finished, the average was still 25 pounds (11.1%) versus 5.3 pounds (2.1%) on placebo - Lilly published both numbers rather than only the flattering one
✓A once-daily tablet, so there is no injection, no needle disposal and no refrigeration to organise
✓Self-pay pricing is published up front at $149 per month for the lowest dose through LillyDirect, with free home delivery
✓Eligible people with commercial insurance may pay as little as $25 per month with the Foundayo savings card
✓Eligible Medicare Part D patients may be able to get it for $50 per month from as early as 1 July 2026 - a rarity in this category
✓Lilly reported reductions in waist circumference, non-HDL cholesterol, triglycerides and systolic blood pressure across all doses
✓It is a small-molecule (non-peptide) GLP-1, which is why it can be manufactured as a pill rather than an injection

Cons

✗Weight loss is meaningfully lower than the best injectables. 12.4% at the top dose sits below tirzepatide territory, so if maximum weight loss is the goal an injection still wins
✗It carries the class boxed warning: it may cause thyroid tumours including thyroid cancer, and must not be used by anyone with a personal or family history of medullary thyroid carcinoma or MEN 2
✗Should not be used alongside another GLP-1 receptor agonist
✗Common side effects include nausea, constipation, diarrhoea, vomiting, indigestion, abdominal pain, headache, fatigue, heartburn, gas and hair loss
✗Serious risks in the label include pancreatitis, dehydration leading to kidney problems, gallbladder problems, severe allergic reactions and aspiration risk under anaesthesia
✗Safety and effectiveness in children have not been established
✗$149 is the price of the lowest dose only - higher doses cost more, and the $25 and $50 figures depend on insurance eligibility rather than being available to everyone
✗Very new to market, so there is no long-term real-world safety and adherence record yet

Choose Foundayo

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Foundayo	Signos
Monthly Price	$149	$127
Rating	9.2/10	7.8/10
Medications	orforglipron	continuous glucose monitoring
Insurance Accepted	Yes	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free home delivery via LillyDirect; shipping began 6 April 2026	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	As directed by your prescriber	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None published; this is a prescription medicine, not a subscription service	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Prescription-based - stopping treatment is a decision for you and your prescriber	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Foundayo if you:

→Prefer a higher-rated service (9.2/10 vs 7.8/10)
→Need insurance coverage for your treatment
→Value: the first and only fda-approved glp-1 pill for weight loss that can be taken at any time of day with no food or water restrictions, approved 1 april 2026

Get started with Foundayo

Choose Signos if you:

→Want to save $22/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Foundayo

Foundayo website

Signos

Signos website

Our recommendation

Foundayo comes out ahead with a higher rating of 9.2/10.

Get started with Foundayo

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