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HealthRX vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

HealthRX vs Signos: Overview

Choosing between HealthRX and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

HealthRX offers both semaglutide and tirzepatide at $133/month with a rating of 8.5/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $6/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$6/mo

Rating Difference

0.7

Winner

HealthRX

Best For

Quality

HealthRX

View full HealthRX review →

Rating

8.5/10Better

Monthly Price

$133

Medications

semaglutidetirzepatide

Pros

✓Efficacy claims are cited to the actual trials with duration and source: 'Average 15% body-weight loss at 68 weeks in STEP-1' for semaglutide and 'Average 21% body-weight loss at 72 weeks in pivotal phase-3 trial' for tirzepatide, referencing NEJM 2021, each followed immediately by 'Not FDA-approved'
✓The competitor price comparison is dated and sourced - 'published monthly prices at comparable telehealth clinics, July 2026' and 'Prices as displayed on each clinic's public site' - rather than an unattributed claim of being cheapest
✓LegitScript certification is given with its certificate number (50087439), so it can be independently verified
✓Pricing is low and clearly tiered: compounded semaglutide from $133/mo on a 3-month plan or $99/mo on 12 months, and tirzepatide from $209/mo or $179/mo on 12 months (checked July 27, 2026)
✓Same price at every dose, so titration does not raise the bill
✓Full refund if a licensed provider does not approve you, and the site states outright that paying does not guarantee a prescription
✓Cancel anytime 'in one click', with free overnight cold-chain shipping and availability in all 50 states
✓The 503A regulatory category is named specifically rather than the vaguer 'FDA-registered facility' language competitors prefer

Cons

✗The '4.8 · 12,000+ members' rating shown in the header has no traceable source - we found no Trustpilot profile for the domain and no other public review platform carrying it
✗The advertised prices are plan prices, not month-to-month rates. '$133/mo' is the 3-month plan and '$99/mo' requires committing to a full year; no single-month price is displayed
✗Committing 12 months upfront to a compounded medication means paying for a year before you know how you tolerate it
✗No BBB profile or independent complaint record exists to check the service against
✗No published customer phone number or support hours
✗The competitor comparison, while dated and sourced, is still marketing produced by the company that benefits from it
✗As with every compounded GLP-1, the trial figures quoted come from the branded medicines rather than the compounded product actually dispensed - HealthRX says so, but the numbers still headline the page

Choose HealthRX

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	HealthRX	Signos
Monthly Price	$133	$127
Rating	8.5/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free overnight shipping, ships cold in 24-48 hours	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Provider review and ongoing support included	Continuous glucose data with in-app dietitian support
Money-back Guarantee	Full refund if a licensed provider does not approve you for treatment	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime in one click; plan prices are paid upfront for the term selected	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose HealthRX if you:

→Prefer a higher-rated service (8.5/10 vs 7.8/10)
→Want more medication options to choose from
→Value: efficacy claims are cited to the actual trials with duration and source: 'average 15% body-weight loss at 68 weeks in step-1' for semaglutide and 'average 21% body-weight loss at 72 weeks in pivotal phase-3 trial' for tirzepatide, referencing nejm 2021, each followed immediately by 'not fda-approved'

Get started with HealthRX

Choose Signos if you:

→Want to save $6/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

HealthRX

HealthRX website

Signos

Signos website

Our recommendation

HealthRX comes out ahead with a higher rating of 8.5/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with HealthRX

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