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Lttl vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Lttl vs Signos: Overview

Choosing between Lttl and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Lttl offers both semaglutide and tirzepatide at $129/month with a rating of 7.9/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $2/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$2/mo

Rating Difference

0.1

Winner

Lttl

Best For

Quality

Lttl

View full Lttl review →

Rating

7.9/10Better

Monthly Price

$129

Medications

semaglutidetirzepatidesermorelinNAD+glutathione

Pros

✓The pricing page shows the complete ladder rather than a teaser, and says so explicitly: 'Every price. Every commitment length. No hidden fees, no starting at, no surprises'
✓Compounded tirzepatide runs $279/mo on rolling monthly billing, $249/mo over 3 months, $229/mo over 6 and $199/mo over 12, against a stated full price of $339/mo (checked July 28, 2026)
✓Weight loss plans start at $129/mo, longevity at $79/mo and microdose at $109/mo
✓'Same price, every dose' - your rate is locked from day one and does not rise as you titrate up. That is a genuine differentiator; several competitors we cover more than double the price between the starting and top dose
✓The compounding disclosure correctly separates 'FDA-registered facility' from 'FDA-approved drug', and states plainly that the medication has not been evaluated by the FDA for safety, efficacy or quality
✓A published phone number, a real California street address, an email address and a help centre - the full set, which is unusual in this category
✓No contracts, cancel anytime, free shipping, and medication prescribed and shipped within 48 hours
✓The assessment is free, takes about two minutes and requires no card up front
✓Longevity and peptide options (sermorelin, NAD+, glutathione, MIC B12) sit alongside the GLP-1 line at lower price points

Cons

✗The advertised '4.9 from 12,000+ Members' does not match the Trustpilot profile, which showed 4.3 from 8 reviews. Displaying that figure beside a Trustpilot badge implies a source it does not have
✗'Average Lttl members lose 32 lbs in first 6 months' and 'Top responders lose 55+ lbs in 12 months' are given without sample size, methodology or whether the weights were self-reported
✗'#1 RATED FOR RESULTS' and '62% of Lttl members choose this plan' carry no source at all
✗The 'Join 500,000+ others' figure is the company's own with no independent corroboration
✗The best rate requires committing to 12 months billed as $2,388 annually, and prescription medication cannot be returned or refunded once it ships - so that is a large non-recoverable commitment
✗Consultation fees are 'generally non-refundable once a provider has reviewed' your case, meaning you can pay and still be declined
✗Microdose plans are sold as a distinct tier at $109/mo, but microdosing is not an evidence-based protocol - the trials behind these drugs used full therapeutic doses
✗Compounded semaglutide and tirzepatide are not FDA-approved, and the weight-loss figures associated with these molecules come from trials of the branded products
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy. Pancreatitis and gallbladder disease are recognised risks

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Lttl	Signos
Monthly Price	$129	$127
Rating	7.9/10	7.8/10
Medications	semaglutide, tirzepatide, sermorelin, NAD+, glutathione	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Unlimited 24/7 support advertised	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Prescribed and shipped within 48 hours, free shipping	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Unlimited 24/7 care team support advertised	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None. Prescription medication is non-returnable once shipped; damaged or incorrect orders replaced if reported within 7 days	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	No contracts, cancel anytime; longer commitments are billed upfront and medication already shipped is non-refundable	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Lttl if you:

→Prefer a higher-rated service (7.9/10 vs 7.8/10)
→Want more medication options to choose from
→Value: the pricing page shows the complete ladder rather than a teaser, and says so explicitly: 'every price. every commitment length. no hidden fees, no starting at, no surprises'

Get started with Lttl

Choose Signos if you:

→Want to save $2/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Lttl

Lttl website

Signos

Signos website

Our recommendation

Lttl comes out ahead with a higher rating of 7.9/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Lttl

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