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MadeMed vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

MadeMed vs Signos: Overview

Choosing between MadeMed and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

MadeMed offers both semaglutide and tirzepatide at $239/month with a rating of 7.3/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $112/month is significant - Signos is the more budget-friendly option, while MadeMed positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$112/mo

Rating Difference

0.5

Winner

Signos

Best For

Budget

MadeMed

View full MadeMed review →

Rating

7.3/10

Monthly Price

$239

Medications

semaglutidetirzepatide

Pros

✓The compounded disclaimer is explicit and sits on the product page itself, not in a distant footer
✓It directs patients to the FDA's adverse event reporting line (1-800-FDA-1088), which almost no competitor does
✓A real customer phone number is published rather than a contact form alone
✓Both semaglutide and tirzepatide are offered in injectable and oral forms
✓Quarterly billing at the starting dose is inexpensive - $239 per refill billed every three months for injectable semaglutide, and $399 for injectable tirzepatide (checked July 27, 2026)
✓The pricing footnote is honest about what it covers: 'Advertised pricing reflects the starting dosage'
✓Peptide and NAD+ lines are available alongside weight care

Cons

✗The monthly purchase option displays a price of '$0*/month'. On the primary buying path for the flagship product, the price simply does not render
✗Pricing is not flat across doses. The footnote states 'Actual price depends on the dosage prescribed by your provider', so the advertised figure applies only at the starting dose and rises as you titrate up - the opposite of the flat-price model most competitors offer, and a significant cost risk over a year
✗The '4.8/5' rating shown on product pages has no traceable source, and no Trustpilot profile exists for the domain
✗The homepage is effectively a navigation shell - it carries menus and a phone number but almost no content, pricing or explanation
✗Product pages are only reachable at bare paths such as /injectable-semaglutide; the more conventional /products/ and /weight-loss/ paths return empty shells
✗No refund or cancellation policy could be found beyond a 'Returns' link
✗No support hours are published, and there is no independent complaint record of any kind
✗Because the real cost depends on the dose you end up on, you cannot work out what a year of treatment will cost before signing up

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	MadeMed	Signos
Monthly Price	$239	$127
Rating	7.3/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Not published	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Board-certified physician review; follow-up frequency not published	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None published; only a 'Returns' link is provided	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Not published; billing is monthly or quarterly per refill	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose MadeMed if you:

→Want more medication options to choose from
→Value: the compounded disclaimer is explicit and sits on the product page itself, not in a distant footer

Get started with MadeMed

Choose Signos if you:

→Want to save $112/month with a more affordable option
→Prefer a higher-rated service (7.8/10 vs 7.3/10)
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

MadeMed

MadeMed website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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