MangoRx vs Sesame Care
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
MangoRx vs Sesame Care: Overview
Choosing between MangoRx and Sesame Care for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
MangoRx offers both semaglutide and tirzepatide at $299/month with a rating of 7.4/10. Sesame Care also provides both semaglutide and tirzepatide at $59/month with a 8.7/10 rating.
The price difference of $240/month is significant - Sesame Care is the more budget-friendly option, while MangoRx positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$240/mo
Rating Difference
1.3
Winner
Sesame Care
Best For
Budget
MangoRx
View full MangoRx review →Rating
7.4/10
Monthly Price
$299
Medications
oral semaglutidetestosteronesildenafiltadalafil
Pros
- ✓Pricing is published without an intake and stated as locked in with no hidden fees: Slim oral semaglutide at $299/month and TRT starting at $99/month (checked July 28, 2026)
- ✓Provider visits and shipping are free on all orders, so there is no separate consultation fee stacked on top
- ✓The TRT program includes a comprehensive lab test and a personalized plan, with a full refund if you do not qualify - so the assessment carries no financial risk
- ✓The compounded-medication disclosure is thorough and correctly worded, including the point that clinical data from FDA-approved drugs may not transfer to compounded versions
- ✓It explicitly disclaims any relationship with Novo Nordisk or Eli Lilly rather than trading on their brand names
- ✓An orally dissolving tablet is a genuine convenience for people who will not inject, and the formulation adds vitamin B6, which the site says is intended to reduce nausea
- ✓Replied to 100% of negative Trustpilot reviews
- ✓A dedicated safety page, pharmacy disclaimer and telehealth consent are all published and dated
Cons
- ✗At $299/month, Slim is one of the more expensive semaglutide options we cover - and it is compounded. For comparison, the FDA-approved oral semaglutide listed elsewhere on this site sits at $149/month, so you would be paying roughly double for a preparation the FDA has not reviewed
- ✗There is no published bioavailability data for this tablet. Approved oral semaglutide relies on an absorption enhancer (SNAC) plus a strict fasting-and-water protocol precisely because semaglutide is a peptide that is poorly absorbed by mouth. Without that data, there is no way to know how much drug a compounded orally dissolving tablet actually delivers
- ✗The weight-loss figures associated with semaglutide - roughly 14.9% of body weight over 68 weeks in the STEP-1 trial - come from weekly subcutaneous injections of the branded drug, not from a compounded oral tablet. Do not assume the results transfer
- ✗The FDA declared the semaglutide shortage resolved in early 2025, after which compounders were required to stop producing what amounts to a copy of an approved drug. Providers still selling compounded semaglutide generally argue their formulation is materially different. It is a fair question to put to the provider before paying
- ✗The refund policy covers dispensing errors, cancellation before filling, and shipping damage reported within 7 days. It does not cover simply not getting on with the treatment
- ✗Only 15 Trustpilot reviews, and no BBB profile, so there is very little independent evidence either way
- ✗No corporate entity, address or phone number appears anywhere on the site - support is a single email address
- ✗This offer is not available in Alabama, Alaska, Arkansas, California, Kentucky, Louisiana, Michigan, Mississippi, North Dakota, South Carolina, South Dakota or Wyoming
- ✗The brand voice leans heavily on bravado - 'MAN. GO.', 'You badass' - which sits oddly against prescribing a GLP-1 and testosterone, where the tone you want is clinical caution
- ✗Semaglutide is not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, and is not for use in pregnancy. Pancreatitis and gallbladder disease are recognised risks
Sesame Care
View full Sesame Care review →Rating
8.7/10Better
Monthly Price
$59Cheaper
Medications
semaglutidetirzepatideorforglipron
Pros
- ✓Publishes cash prices dose by dose, which no other provider on this site does. Zepbound KwikPen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
- ✓The same detail applies across the range: Wegovy pill $149/mo (1.5mg, 4mg) or $299 (9mg, 25mg); Wegovy pen $199 for the first two months for new patients then $349; Foundayo from $149 to $349 depending on dose (checked July 27, 2026)
- ✓Every medication offered is FDA-approved and branded - no compounded product is involved
- ✓Insurance is accepted, and with coverage medication can drop to as low as $25/mo
- ✓The care programme itself - video visits, dedicated provider, labs and messaging - starts at $59/mo
- ✓Efficacy milestones are properly sourced, citing a study of injectable semaglutide 2.4mg with the population spelled out (BMI 30+, or 27+ with a weight-related condition, non-diabetic) and paired with lifestyle change
- ✓A full refund is available if you cancel at least three hours before your first visit
- ✓The wider marketplace lets you compare individual providers on price, with appointments from $37
Cons
- ✗The $59/mo headline depends on a 12-month 'Success by Sesame' commitment, and the annual fee is explicitly non-refundable once paid - cancel in month two and you do not get the remaining ten months back
- ✗Medication costs are not included in the programme price, which Sesame states plainly but which means the real monthly outlay is the subscription plus the drug
- ✗Cash prices escalate steeply with dose. Zepbound more than doubles from $299 to $698 as you titrate to a maintenance dose, so the entry price is not the price you will end up paying
- ✗The Wegovy pen intro rate of $199 applies to new patients only and for two months, after which it is $349
- ✗Monthly subscribers are not refunded for months already paid, even if unused
- ✗Because pricing depends on insurance status, pharmacy and dose, there is no single figure you can plan around before signing up
- ✗This is a general healthcare marketplace, so the weight-loss programme sits alongside urgent care and prescription refills rather than being a dedicated speciality service
Feature-by-feature comparison
| Feature | MangoRx | Sesame Care |
|---|---|---|
| Monthly Price | $299 | $59 |
| Rating | 7.4/10 | 8.7/10 |
| Medications | oral semaglutide, testosterone, sildenafil, tadalafil | semaglutide, tirzepatide, orforglipron |
| Insurance Accepted | No | Yes |
| Support Hours | Not published | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | No |
| Shipping Speed | Free discreet shipping on all orders; Slim ships monthly as a 30-day supply | Filled at your pharmacy; not shipped by Sesame |
| Mobile App | No | Available |
| Dedicated Coach | Not included | Included |
| Follow-up Frequency | Doctor-managed plans with lab-based adjustment on TRT; cadence not published | Ongoing video visits, labs and messaging with a dedicated provider |
| Money-back Guarantee | Full refund on TRT if you do not qualify. Otherwise refunds are limited to dispensing errors, pre-fill cancellation, or shipping damage reported within 7 days | Full refund if you cancel at least 3 hours before your first visit; annual fees are non-refundable once paid |
| Cancellation Policy | Monthly supply; cancellation before a prescription is filled is refundable, subject to the cancellation policy | Self-cancel monthly or annual subscriptions any time, but past months and annual fees are not refunded |
Which should you choose?
Choose MangoRx if you:
- →Want more medication options to choose from
- →Value: pricing is published without an intake and stated as locked in with no hidden fees: slim oral semaglutide at $299/month and trt starting at $99/month (checked july 28, 2026)
Choose Sesame Care if you:
- →Want to save $240/month with a more affordable option
- →Prefer a higher-rated service (8.7/10 vs 7.4/10)
- →Need insurance coverage for your treatment
- →Want personalized coaching support included
- →Value: publishes cash prices dose by dose, which no other provider on this site does. zepbound kwikpen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
Website previews
MangoRx
Sesame Care
Our recommendation
Sesame Care comes out ahead with a higher rating of 8.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.
Get started with Sesame CareRelated comparisons
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