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MEDVi Quad vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

MEDVi Quad vs Signos: Overview

Choosing between MEDVi Quad and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

MEDVi Quad offers both semaglutide and tirzepatide at $114/month with a rating of 6.5/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $13/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$13/mo

Rating Difference

1.3

Winner

Signos

Best For

Quality

MEDVi Quad

View full MEDVi Quad review →

Rating

6.5/10

Monthly Price

$114Cheaper

Medications

sildenafiltadalafilbremelanotide (PT-141)L-citrulline

Pros

✓$114/month, reduced from a stated $179, and the price is all-in: doctor consultation, free rush shipping and 24/7 medical support are included with no separate consultation fee (checked July 28, 2026)
✓Cancel anytime, and the page states you are not charged if you do not qualify
✓All four active ingredients are named openly - PT-141 (bremelanotide), L-citrulline, sildenafil and tadalafil - rather than hidden behind a proprietary blend name
✓Sublingual delivery is a real advantage over tablets: it bypasses first-pass metabolism, so onset is faster and a heavy meal does not blunt absorption the way it can with oral sildenafil
✓Backed by a substantial independent review record - roughly 14,000 Trustpilot reviews at 4.4, with 99% of negative reviews answered
✓A published phone number, email address and physical address, which many competitors in this category omit entirely

Cons

✗'Peak rigidity guaranteed' appears directly in the product copy. No prescription medication can guarantee an outcome, and this is the most explicit outcome promise we have seen across every provider reviewed on this site
✗The formula stacks two PDE5 inhibitors - sildenafil and tadalafil - and then adds L-citrulline, a nitric oxide precursor. All three act on the same nitric oxide and cGMP pathway, so the blood-pressure-lowering effect compounds three ways rather than one
✗PT-141 adds a fourth agent that independently causes low blood pressure, nausea and flushing. Four actives, four routes to hypotension, and no discussion anywhere on the page of the combined risk
✗Bremelanotide's only FDA approval is as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Prescribing it to men in a compounded sublingual liquid is off-label and a different route of administration
✗The word FDA does not appear on the page at all. The product is compounded, and the page never states the consequence - that compounded preparations are not reviewed or approved by the FDA for safety, efficacy or quality
✗'The world's first 4-in-1 formula' and 'hospital-grade power' are unverifiable marketing superlatives attached to a prescription product
✗The advertised Trustpilot score covers MEDVi's business as a whole rather than this specific product
✗The published address is a suite at a Delaware registered-agent building, not a clinical facility
✗Anyone taking nitrates or riociguat must not use this product. The PT-141 component also interacts with 5-HT3 anti-emetics such as ondansetron, and stacking two PDE5 inhibitors makes the nitrate contraindication more dangerous, not less

Choose MEDVi Quad

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	MEDVi Quad	Signos
Monthly Price	$114	$127
Rating	6.5/10	7.8/10
Medications	sildenafil, tadalafil, bremelanotide (PT-141), L-citrulline	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	24/7 medical support advertised	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free rush shipping included in the monthly price	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	24/7 medical support advertised; follow-up cadence not published	Continuous glucose data with in-app dietitian support
Money-back Guarantee	No charge if you do not qualify; no refund policy published for dispensed medication	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose MEDVi Quad if you:

→Want to save $13/month with a more affordable option
→Want more medication options to choose from
→Value: $114/month, reduced from a stated $179, and the price is all-in: doctor consultation, free rush shipping and 24/7 medical support are included with no separate consultation fee (checked july 28, 2026)

Get started with MEDVi Quad

Choose Signos if you:

→Prefer a higher-rated service (7.8/10 vs 6.5/10)
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

MEDVi Quad

MEDVi Quad website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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