Refills vs Shameless Care
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Refills vs Shameless Care: Overview
Choosing between Refills and Shameless Care for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
Refills offers both semaglutide and tirzepatide at $150/month with a rating of 7.8/10. Shameless Care also provides both semaglutide and tirzepatide at $109/month with a 8/10 rating.
With only a $41/month price difference, your choice will likely come down to features, support quality, and medication options.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$41/mo
Rating Difference
0.2
Winner
Shameless Care
Best For
Budget
Refills
View full Refills review →Rating
7.8/10
Monthly Price
$150
Medications
semaglutidetirzepatide
Pros
- ✓The largest verifiable review base of any provider in this batch: the Trustpilot profile for refills.com showed a 4-star TrustScore from roughly 1,244 reviews when we checked
- ✓No membership or app fees, stated as a headline promise: "Never Pay for Monthly Memberships or App Fees"
- ✓All dosages cost the same - "We don't charge you based on dosage changes" - which removes the titration price trap that catches most compounded GLP-1 patients
- ✓Both a GLP-1 (semaglutide-class) and a GIP + GLP-1 (tirzepatide-class) injectable are offered
- ✓A published phone number, 888-458-5061, and support@refills.com, with 24/7 health-concierge support advertised
- ✓Free and discreet shipping on every order
- ✓Unusually candid disclaimers: it states plainly that compounded drug products are not approved or evaluated by the FDA, and that Refills Health is not a medical services provider but a technology platform
- ✓It names its clinical partners - Beluga Health, Bask Health and Wasef Health - rather than referring vaguely to "our providers"
- ✓Certificates of Analysis are available on request for any batch
- ✓LegitScript certification is displayed
Cons
- ✗Pricing is quoted per day, not per month. "GLP-1s from $5/day" reads as cheap but is $150 a month, and the site never states a monthly figure
- ✗Refills is a technology platform, not a medical provider. It does not manufacture or dispense medication and does not employ the clinicians who prescribe
- ✗All prescription sales are final. State and federal rules do not allow returns of dispensed prescription medication, and once your card is charged and the package is handed to the carrier there is no refund
- ✗Returns are only accepted on unopened, non-prescription items within 30 days, and you pay the return shipping
- ✗It does not ship refrigerated products, which the returns page presents as a benefit ("your product will not be affected by increased transit time") but which is worth understanding before you order
- ✗The medication is compounded, so it has not been evaluated by the FDA for safety, quality or efficacy
- ✗Available across the US but explicitly not in the District of Columbia
- ✗Before/after testimonials headline losses of 40 to 120 pounds. The disclaimer that results are not typical is present but far less prominent than the numbers
Shameless Care
View full Shameless Care review →Rating
8/10Better
Monthly Price
$109Cheaper
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
Feature-by-feature comparison
| Feature | Refills | Shameless Care |
|---|---|---|
| Monthly Price | $150 | $109 |
| Rating | 7.8/10 | 8/10 |
| Medications | semaglutide, tirzepatide | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline |
| Insurance Accepted | No | No |
| Support Hours | Company advertises free 24/7 support from a health concierge | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Free shipping; non-refrigerated products shipped via USPS, FedEx or UPS | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost |
| Mobile App | No | No |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | Providers reassess and adjust dose, titration pace or treatment on request | Board-certified physician assigned from start to finish; ongoing cadence not published |
| Money-back Guarantee | None. All prescription sales are final once dispatched | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published |
| Cancellation Policy | You can log in and cancel your subscription, change your address or change your payment method any time before the order is sent to the pharmacy | No subscriptions - every purchase is one-off, so there is nothing to cancel |
Which should you choose?
Choose Refills if you:
- →Value: the largest verifiable review base of any provider in this batch: the trustpilot profile for refills.com showed a 4-star trustscore from roughly 1,244 reviews when we checked
Choose Shameless Care if you:
- →Want to save $41/month with a more affordable option
- →Prefer a higher-rated service (8/10 vs 7.8/10)
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Website previews
Refills
Shameless Care
Our recommendation
Shameless Care comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.
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