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Refills vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Refills vs Signos: Overview

Choosing between Refills and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Refills offers both semaglutide and tirzepatide at $150/month with a rating of 7.8/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $23/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$23/mo

Rating Difference

0.0

Winner

Signos

Best For

Budget

Refills

View full Refills review →

Rating

7.8/10

Monthly Price

$150

Medications

semaglutidetirzepatide

Pros

✓The largest verifiable review base of any provider in this batch: the Trustpilot profile for refills.com showed a 4-star TrustScore from roughly 1,244 reviews when we checked
✓No membership or app fees, stated as a headline promise: "Never Pay for Monthly Memberships or App Fees"
✓All dosages cost the same - "We don't charge you based on dosage changes" - which removes the titration price trap that catches most compounded GLP-1 patients
✓Both a GLP-1 (semaglutide-class) and a GIP + GLP-1 (tirzepatide-class) injectable are offered
✓A published phone number, 888-458-5061, and support@refills.com, with 24/7 health-concierge support advertised
✓Free and discreet shipping on every order
✓Unusually candid disclaimers: it states plainly that compounded drug products are not approved or evaluated by the FDA, and that Refills Health is not a medical services provider but a technology platform
✓It names its clinical partners - Beluga Health, Bask Health and Wasef Health - rather than referring vaguely to "our providers"
✓Certificates of Analysis are available on request for any batch
✓LegitScript certification is displayed

Cons

✗Pricing is quoted per day, not per month. "GLP-1s from $5/day" reads as cheap but is $150 a month, and the site never states a monthly figure
✗Refills is a technology platform, not a medical provider. It does not manufacture or dispense medication and does not employ the clinicians who prescribe
✗All prescription sales are final. State and federal rules do not allow returns of dispensed prescription medication, and once your card is charged and the package is handed to the carrier there is no refund
✗Returns are only accepted on unopened, non-prescription items within 30 days, and you pay the return shipping
✗It does not ship refrigerated products, which the returns page presents as a benefit ("your product will not be affected by increased transit time") but which is worth understanding before you order
✗The medication is compounded, so it has not been evaluated by the FDA for safety, quality or efficacy
✗Available across the US but explicitly not in the District of Columbia
✗Before/after testimonials headline losses of 40 to 120 pounds. The disclaimer that results are not typical is present but far less prominent than the numbers

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Refills	Signos
Monthly Price	$150	$127
Rating	7.8/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Company advertises free 24/7 support from a health concierge	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free shipping; non-refrigerated products shipped via USPS, FedEx or UPS	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Providers reassess and adjust dose, titration pace or treatment on request	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None. All prescription sales are final once dispatched	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	You can log in and cancel your subscription, change your address or change your payment method any time before the order is sent to the pharmacy	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Refills if you:

→Want more medication options to choose from
→Value: the largest verifiable review base of any provider in this batch: the trustpilot profile for refills.com showed a 4-star trustscore from roughly 1,244 reviews when we checked

Get started with Refills

Choose Signos if you:

→Want to save $23/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Refills

Refills website

Signos

Signos website

Our recommendation

Signos offers better value at $127/month while maintaining strong ratings.

Get started with Signos

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