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SkinnyRx vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

SkinnyRx vs Signos: Overview

Choosing between SkinnyRx and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

SkinnyRx offers both semaglutide and tirzepatide at $199/month with a rating of 8/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $72/month is significant - Signos is the more budget-friendly option, while SkinnyRx positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$72/mo

Rating Difference

0.2

Winner

SkinnyRx

Best For

Quality

SkinnyRx

View full SkinnyRx review →

Rating

8/10Better

Monthly Price

$199

Medications

semaglutidetirzepatide

Pros

✓Trustpilot rating of 4.8 across 5,272 reviews, an unusually strong independent signal for this category
✓Publishes a customer phone number, +1 (888) 979-9580, and a support email rather than hiding behind a portal
✓Full refund available any time before a licensed provider completes your prescription
✓Compounded injectable semaglutide from $199/month and tirzepatide, as tablets or injection, from $299/month, with microdose options (checked July 26, 2026)
✓Carefully separates compounded from brand-name in its own disclosures instead of implying the two are the same
✓Buy-now-pay-later through Affirm with the APR disclosed openly - the site gives a worked example of $800 split into 12 payments of $72.21 at 15% APR
✓A mobile app for meal plans, medication tracking and weight logging, plus unlimited provider messaging and free shipping
✓A substantial clinical content library covering practical issues like GLP-1s with levothyroxine, gallbladder pain and surgery timing

Cons

✗A '90-day money-back guarantee' is advertised in a banner on every page, but the site's own /money-back-guarantee link returns a 404 reading 'Page not found... Probably the link is broken'. We could not find the terms of that guarantee anywhere
✗The hero promises 'FDA-approved Wegovy, Foundayo and other GLP-1s', yet both the Wegovy Pill and Foundayo Pill are marked 'Unavailable' in the product list directly below
✗Pricing is at the higher end for compounded product: $199/month for semaglutide and $299/month for tirzepatide, where several rivals advertise under $150
✗'Lose up to 14.9% of your body weight' takes the figure from the STEP 1 trial of branded semaglutide and applies it to a compounded preparation that has not been trialled
✗The published refund window closes as soon as a provider completes your prescription, which can be the same day you sign up
✗A pop-up offers 'up to 43% off' without stating what plan or commitment unlocks that discount
✗No BBB profile or complaint history to cross-check the Trustpilot score against
✗No published support hours, so the phone line's availability is unknown

Choose SkinnyRx

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	SkinnyRx	Signos
Monthly Price	$199	$127
Rating	8/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Not published	Free shipping; six-month plans ship in three-month bundles
Mobile App	Available	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Unlimited provider messaging plus app-based tracking	Continuous glucose data with in-app dietitian support
Money-back Guarantee	A 90-day money-back guarantee is advertised sitewide, but its terms page returns a 404; a full refund is available before a provider completes your prescription	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime; full refund only before the prescription is completed by a provider	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose SkinnyRx if you:

→Prefer a higher-rated service (8/10 vs 7.8/10)
→Want more medication options to choose from
→Value: trustpilot rating of 4.8 across 5,272 reviews, an unusually strong independent signal for this category

Get started with SkinnyRx

Choose Signos if you:

→Want to save $72/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

SkinnyRx

SkinnyRx website

Signos

Signos website

Our recommendation

SkinnyRx comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with SkinnyRx

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