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System Labs vs Calibrate

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

System Labs vs Calibrate: Overview

Choosing between System Labs and Calibrate for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

System Labs offers both semaglutide and tirzepatide at $149/month with a rating of 6.5/10. Calibrate also provides both semaglutide and tirzepatide at $199/month with a 8.5/10 rating.

With only a $50/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$50/mo

Rating Difference

2.0

Winner

Calibrate

Best For

Quality

System Labs

View full System Labs review →

Rating

6.5/10

Monthly Price

$149Cheaper

Medications

NAD+sermorelinglutathioneMIC + B12GHK-Cu

Pros

✓Prices are published openly for every product, with the renewal rate shown alongside the introductory one: NAD+ $89 first month then $149, sermorelin $109 then $219, glutathione $79 then $149, oral sermorelin $79 then $159, MIC + B12 $89/mo and GHK-Cu cream $109/mo (checked July 28, 2026)
✓Three delivery formats for NAD+ - injection, nasal spray and liposomal liquid - so needle-free options exist
✓Products are described as American made and third-party tested
✓The intake is short and a licensed provider reviews it before anything ships, with free 2-day shipping
✓No insurance required and no membership fee stacked on top of the product price

Cons

✗This is not a GLP-1 weight loss service. System Labs sells no semaglutide, no tirzepatide and no GLP-1 of any kind - the words do not appear anywhere on its site. If you are shopping for weight loss medication, this provider cannot supply it
✗We could not find any statement that the compounded peptides are not FDA-approved. That disclosure is standard across this category and its absence is the single biggest gap on the site
✗There is no refund or cancellation policy published at all - only a privacy policy and terms page
✗No independent review signal exists: no Trustpilot profile, no BBB file, and no rating displayed on site
✗Introductory pricing roughly doubles at renewal on most products, and the renewal price is the one you will pay for the rest of the course
✗Sermorelin, GHK-Cu and high-dose NAD+ have limited published human trial evidence for the benefits implied - 'perform 10 years younger' style claims are not supported by the kind of trials that back GLP-1 medications
✗No published phone number, support hours or physical address
✗The 'up to 1600mg' NAD+ potency claim is presented as an advantage without any evidence that higher doses produce better outcomes

Choose System Labs

Calibrate

View full Calibrate review →

Rating

8.5/10Better

Monthly Price

$199

Medications

semaglutidetirzepatide

Pros

✓Prescribes only brand-name, FDA-approved GLP-1s - Zepbound, Mounjaro, Wegovy, Ozempic and Foundayo - with no compounded products
✓Publishes a genuine long-term outcome: 20% weight loss achieved at three years, which is a far longer follow-up than the 68-72 week trial data most providers cite
✓Includes 1:1 video coaching and lifestyle support rather than shipping medication and leaving you to it
✓Dedicated insurance navigation support to get the medication covered, instead of assuming cash-pay
✓Available either directly as an individual or through a participating employer
✓Starting price is published openly at $199/month (checked July 28, 2026)

Cons

✗At $199/month for the programme, this is a coaching-led service and the medication cost is separate - what you pay in total depends on your insurance
✗The $199 figure is a 'starting at' price
✗Because it only prescribes brand-name GLP-1s, cost without insurance coverage will be substantially higher than compounded alternatives
✗The 4.5 rating from 1,618 reviews is displayed on Calibrate's own site rather than an independent platform
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy

Choose Calibrate

Feature-by-feature comparison

Feature	System Labs	Calibrate
Monthly Price	$149	$199
Rating	6.5/10	8.5/10
Medications	NAD+, sermorelin, glutathione, MIC + B12, GHK-Cu	semaglutide, tirzepatide
Insurance Accepted	No	Yes
Support Hours	Medical team availability advertised; hours not published	Not published
Live Chat	Available	No
Free Shipping	Yes	No
Shipping Speed	Free 2-day shipping	Prescriptions filled through your pharmacy
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Ongoing clinician support advertised; frequency not published	1:1 video coaching throughout the Metabolic Reset programme
Money-back Guarantee	None published	None published
Cancellation Policy	Not published	Programme based; terms not published

Which should you choose?

Choose System Labs if you:

→Want to save $50/month with a more affordable option
→Want more medication options to choose from
→Value: prices are published openly for every product, with the renewal rate shown alongside the introductory one: nad+ $89 first month then $149, sermorelin $109 then $219, glutathione $79 then $149, oral sermorelin $79 then $159, mic + b12 $89/mo and ghk-cu cream $109/mo (checked july 28, 2026)

Get started with System Labs

Choose Calibrate if you:

→Prefer a higher-rated service (8.5/10 vs 6.5/10)
→Need insurance coverage for your treatment
→Want personalized coaching support included
→Value: prescribes only brand-name, fda-approved glp-1s - zepbound, mounjaro, wegovy, ozempic and foundayo - with no compounded products

Get started with Calibrate

Website previews

System Labs

System Labs website

Calibrate

Calibrate website

Our recommendation

Calibrate comes out ahead with a higher rating of 8.5/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Calibrate

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