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System Labs vs Shed

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

System Labs vs Shed: Overview

Choosing between System Labs and Shed for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

System Labs offers both semaglutide and tirzepatide at $149/month with a rating of 6.5/10. Shed also provides both semaglutide and tirzepatide at $159/month with a 8.1/10 rating.

With only a $10/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$10/mo

Rating Difference

1.6

Winner

Shed

Best For

Quality

System Labs

View full System Labs review →

Rating

6.5/10

Monthly Price

$149Cheaper

Medications

NAD+sermorelinglutathioneMIC + B12GHK-Cu

Pros

✓Prices are published openly for every product, with the renewal rate shown alongside the introductory one: NAD+ $89 first month then $149, sermorelin $109 then $219, glutathione $79 then $149, oral sermorelin $79 then $159, MIC + B12 $89/mo and GHK-Cu cream $109/mo (checked July 28, 2026)
✓Three delivery formats for NAD+ - injection, nasal spray and liposomal liquid - so needle-free options exist
✓Products are described as American made and third-party tested
✓The intake is short and a licensed provider reviews it before anything ships, with free 2-day shipping
✓No insurance required and no membership fee stacked on top of the product price

Cons

✗This is not a GLP-1 weight loss service. System Labs sells no semaglutide, no tirzepatide and no GLP-1 of any kind - the words do not appear anywhere on its site. If you are shopping for weight loss medication, this provider cannot supply it
✗We could not find any statement that the compounded peptides are not FDA-approved. That disclosure is standard across this category and its absence is the single biggest gap on the site
✗There is no refund or cancellation policy published at all - only a privacy policy and terms page
✗No independent review signal exists: no Trustpilot profile, no BBB file, and no rating displayed on site
✗Introductory pricing roughly doubles at renewal on most products, and the renewal price is the one you will pay for the rest of the course
✗Sermorelin, GHK-Cu and high-dose NAD+ have limited published human trial evidence for the benefits implied - 'perform 10 years younger' style claims are not supported by the kind of trials that back GLP-1 medications
✗No published phone number, support hours or physical address
✗The 'up to 1600mg' NAD+ potency claim is presented as an advantage without any evidence that higher doses produce better outcomes

Choose System Labs

Shed

View full Shed review →

Rating

8.1/10Better

Monthly Price

$159

Medications

semaglutidetirzepatide

Pros

✓Compounded semaglutide advertised from $159/mo and compounded tirzepatide from $239/mo, alongside brand-name Wegovy, Zepbound and the new Foundayo pill (checked July 26, 2026)
✓Three delivery formats: weekly injections, daily sublingual liquid drops and daily lozenges, so needle-free options are genuinely available
✓A 120-day weight loss guarantee that is actually written into the terms with defined conditions, rather than an unexplained banner claim
✓The arbitration clause and class action waiver can be opted out of within 30 days of accepting the terms
✓Buy-now-pay-later refunds are handled explicitly: Shed transmits refunds to Affirm, Klarna or Afterpay within three business days, and the terms state each lender's refund window
✓Non-GLP-1 options too - metformin, naltrexone, topiramate, MIC + B12 - so a provider has alternatives if a GLP-1 is not appropriate
✓Health coaching and a member success manager are part of the program, not an upsell
✓Members enrolled under a previous guarantee are grandfathered rather than moved to worse terms

Cons

✗The '120-Day Weight Loss Guarantee' is far more demanding than the asterisk suggests. To qualify you must log at least two weigh-ins a month (eight over the period), complete at least 50% of daily app check-ins - 60 days out of 120 - and submit every provider follow-up form on time. Miss the check-in quota and the guarantee lapses
✗The guarantee only pays out if you fail to lose 5% of your baseline body weight, so modest results still disqualify you from a refund
✗Trustpilot showed 1.8 out of 5, albeit from just 22 reviews - a small but uniformly poor public signal
✗Oral formats are not available in Alaska, Alabama, Arkansas, Connecticut, Indiana, Kentucky, Louisiana, Michigan, Minnesota, North Carolina, New Jersey, South Carolina, Virginia, Vermont, Wisconsin or West Virginia
✗'As low as $159' is a floor price; the site does not publish the plan ladder or say what commitment that rate requires
✗Shed's own product menu misspells its second GLP-1 as 'Compounded Trizepatide', which is not reassuring on a prescription page
✗The compounded products are not FDA-approved, and the '15%' and '20%' body-weight figures on the landing page come from trials of the branded drugs
✗Disputes go to binding arbitration unless you actively opt out in the first 30 days

Feature-by-feature comparison

Feature	System Labs	Shed
Monthly Price	$149	$159
Rating	6.5/10	8.1/10
Medications	NAD+, sermorelin, glutathione, MIC + B12, GHK-Cu	semaglutide, tirzepatide
Insurance Accepted	No	No
Support Hours	Medical team availability advertised; hours not published	Not published
Live Chat	Available	No
Free Shipping	Yes	Yes
Shipping Speed	Free 2-day shipping	Not published
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Ongoing clinician support advertised; frequency not published	Daily app check-ins expected under the guarantee, plus provider follow-up forms
Money-back Guarantee	None published	120-day guarantee, but only if you complete 60 daily app check-ins, 8 weigh-ins and every provider form, and still fail to lose 5% of baseline body weight
Cancellation Policy	Not published	Subscription based; refunds are governed by the 120-day guarantee conditions, with BNPL refunds transmitted within 3 business days

Which should you choose?

Choose System Labs if you:

→Want to save $10/month with a more affordable option
→Want more medication options to choose from
→Value: prices are published openly for every product, with the renewal rate shown alongside the introductory one: nad+ $89 first month then $149, sermorelin $109 then $219, glutathione $79 then $149, oral sermorelin $79 then $159, mic + b12 $89/mo and ghk-cu cream $109/mo (checked july 28, 2026)

Get started with System Labs

Choose Shed if you:

→Prefer a higher-rated service (8.1/10 vs 6.5/10)
→Want personalized coaching support included
→Value: compounded semaglutide advertised from $159/mo and compounded tirzepatide from $239/mo, alongside brand-name wegovy, zepbound and the new foundayo pill (checked july 26, 2026)

Get started with Shed

Website previews

System Labs

System Labs website

Shed

Shed website

Our recommendation

Shed comes out ahead with a higher rating of 8.1/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Shed

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