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TMates vs Winona

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

TMates vs Winona: Overview

Choosing between TMates and Winona for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

TMates offers both semaglutide and tirzepatide at $249/month with a rating of 7.8/10. Winona also provides both semaglutide and tirzepatide at $89/month with a 8.4/10 rating.

The price difference of $160/month is significant - Winona is the more budget-friendly option, while TMates positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$160/mo

Rating Difference

0.6

Winner

Winona

Best For

Budget

TMates

View full TMates review →

Rating

7.8/10

Monthly Price

$249

Medications

semaglutidetirzepatide

Pros

✓Both price ladders are published in full and the arithmetic is correct at every tier. Semaglutide runs $249 for one month, $217/mo over three ($650), $175/mo over six ($1,050) and $158/mo over twelve ($1,900), checked July 27, 2026
✓Tirzepatide is laid out the same way: $297 monthly, $267/mo over three ($800), $217/mo over six ($1,299) and $167/mo over twelve ($1,999)
✓Every advertised saving checks out - the 13%, 30%, 37%, 10%, 27% and 44% figures all match the underlying numbers
✓One price across all doses, from 0.25mg to 2.4mg semaglutide and 2.5mg to 15mg tirzepatide, so titrating up never costs more
✓Possible side effects are listed openly on the product page - nausea, injection site reactions, decreased appetite and gastrointestinal discomfort - with a note that most are mild and temporary
✓Both injectable and oral formats are offered at the same published prices
✓Medication, provider review, personalised dosing and ongoing support are all included in the price, with free shipping and cancel-anytime terms

Cons

✗We could not find an explicit statement that the compounded medications are not FDA-approved. The site explains what compounding is but omits the disclosure nearly every competitor makes
✗Trustpilot has exactly one review of this domain, so there is effectively no independent evidence about the service against a claim of 2,400+ patients
✗Tirzepatide is billed as the 'Most powerful GLP-1 medication available' - a superiority claim made about a compounded preparation that has not been trialled against anything
✗The 'up to 15% of their body weight in a year' figure is presented as what TMates has seen in its own patients, with no published data behind it
✗The lowest advertised rates require paying for a full year upfront - $1,900 for semaglutide or $1,999 for tirzepatide
✗The site is behind bot protection and will not load without JavaScript, so pricing is invisible to anyone browsing with scripts disabled
✗No published customer phone number, support email or support hours
✗No BBB profile or complaint record to check

Winona

View full Winona review →

Rating

8.4/10Better

Monthly Price

$89Cheaper

Medications

bioidentical estradiolprogesteroneestriolDHEAsildenafilminoxidil

Pros

✓The full price list is published openly, with no intake required to see it: progesterone capsules from $39/mo, estrogen tablets from $54/mo, estrogen body cream (with progesterone) from $89/mo, vaginal estrogen cream from $89/mo and the estrogen patch from $149/mo (checked July 28, 2026)
✓Multiple delivery routes are offered - patch, body cream, vaginal cream, tablet and capsule - so treatment can be matched to preference rather than to whatever the company happens to stock
✓Winona owns its own 503A compounding pharmacies rather than outsourcing to a partner, which gives it direct control over formulation and consistency
✓Its pharmacy page explains the 503A/503B distinction correctly and states that 503A pharmacies are regulated by State Boards of Pharmacy, not the FDA - an accurate description that competitors routinely overstate
✓Roughly 8,000 Trustpilot reviews at 4.6, with 99% of negative reviews answered and a typical reply time under 24 hours
✓The rating advertised on site matches the rating on the public Trustpilot profile
✓The initial visit is free, so you can be assessed before paying for treatment
✓Editorial content carries numbered citations rather than unsourced assertions, and the site runs a public subreddit alongside a help centre and published phone number
✓HSA/FSA eligible, with a dedicated page explaining eligibility
✓Adjacent products are priced transparently too - DHEA from $27 per 3-month supply, sildenafil arousal cream at $79 per order, minoxidil hair serum at $150 per 3-month supply

Cons

✗Everything Winona dispenses is compounded in its own 503A pharmacies, which means it is not FDA-approved and has not been evaluated by the FDA for safety, efficacy or quality. The site explains 503A status clearly but does not foreground the 'not FDA-approved' consequence as plainly
✗Pharmaceutical products cannot be returned, per the terms - so once a prescription ships, you own it
✗The terms carry a mandatory arbitration clause on an individual basis with a class-action waiver, set out in capitals at the top of the document
✗Every headline price is a 'from' figure, so the actual monthly cost depends on the dose your clinician prescribes and is not knowable before the consultation
✗The hormone therapy explainer describes HRT as 'scientifically proven to be the safest, most effective treatment' for menopause symptoms. It is cited, but that is a strong framing for a therapy whose risk profile still depends heavily on age, time since menopause and personal history
✗Trustpilot notes Winona invites customers to review, which tends to lift scores relative to organic-only profiles, and that it may use AI-assisted replies
✗Systemic estrogen is not appropriate for everyone - women with a history of breast or endometrial cancer, unexplained vaginal bleeding, blood clots, stroke or liver disease should not start it without specialist input
✗Compounded hormone therapy in general lacks the long-term outcome data that exists for FDA-approved products, so the evidence cited for HRT as a class does not transfer automatically to these specific preparations

Feature-by-feature comparison

Feature	TMates	Winona
Monthly Price	$249	$89
Rating	7.8/10	8.4/10
Medications	semaglutide, tirzepatide	bioidentical estradiol, progesterone, estriol, DHEA, sildenafil, minoxidil
Insurance Accepted	No	No
Support Hours	Not published	Help centre and chat available; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free shipping; timeframe not published	Shipped to your door after clinician review; free shipping included
Mobile App	No	No
Dedicated Coach	Not included	Not included
Follow-up Frequency	Ongoing provider support included	Ongoing clinician access through the patient portal; cadence not published
Money-back Guarantee	None published	None published; pharmaceutical products cannot be returned. A separate cancellation and refund policy governs subscriptions
Cancellation Policy	Cancel anytime, but multi-month plans are paid upfront	Subscriptions can be cancelled from your account; a separate cancellation policy governs when it takes effect

Which should you choose?

Choose TMates if you:

→Value: both price ladders are published in full and the arithmetic is correct at every tier. semaglutide runs $249 for one month, $217/mo over three ($650), $175/mo over six ($1,050) and $158/mo over twelve ($1,900), checked july 27, 2026

Get started with TMates

Choose Winona if you:

→Want to save $160/month with a more affordable option
→Prefer a higher-rated service (8.4/10 vs 7.8/10)
→Want more medication options to choose from
→Value: the full price list is published openly, with no intake required to see it: progesterone capsules from $39/mo, estrogen tablets from $54/mo, estrogen body cream (with progesterone) from $89/mo, vaginal estrogen cream from $89/mo and the estrogen patch from $149/mo (checked july 28, 2026)

Get started with Winona

Website previews

TMates

TMates website

Winona

Winona website

Our recommendation

Winona comes out ahead with a higher rating of 8.4/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Winona

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