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TrimRx vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

TrimRx vs Signos: Overview

Choosing between TrimRx and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

TrimRx offers both semaglutide and tirzepatide at $199/month with a rating of 7.4/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $72/month is significant - Signos is the more budget-friendly option, while TrimRx positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$72/mo

Rating Difference

0.4

Winner

Signos

Best For

Budget

TrimRx

View full TrimRx review →

Rating

7.4/10

Monthly Price

$199

Medications

semaglutidetirzepatide

Pros

✓Published tier pricing you can read before you sign up: compounded GLP-1 at $174/mo month-to-month, $166 (3-month), $158 (6-month) or $149 (12-month); GLP-1 + GIP at $279, $266, $258 and $249 (checked July 26, 2026)
✓Same price at every dose, so your cost does not climb as you titrate up
✓The monthly fee bundles the telehealth visit, the medication, shipping and ongoing support - there is no separate consultation charge
✓Free 2-day shipping, and the terms commit to dispatch within 48 business hours of prescription approval
✓Unusually candid legal terms: TrimRx states in writing that compounded medications are not FDA-approved and makes no claim they are equivalent to the branded drugs
✓Providers will also write prescriptions for FDA-approved Ozempic ($1,299/mo) or Zepbound ($1,399/mo), fulfilled on a limited basis
✓BBB accredited since June 2025 and a LegitScript seal on site, with a real San Diego business address and published phone number
✓Available in all 50 states, with no insurance required

Cons

✗The advertised price is not the ongoing price. The terms list the GLP-1 follow-up month at $299 and GLP-1 + GIP at $399, while landing pages headline $149-$174. Those low rates require paying 3 to 12 months upfront
✗The 'lose weight or your money back' guarantee is contradicted twice over: the same landing page's disclaimer says weight loss is not guaranteed, and the refund policy allows refunds only for medical disqualification or a TrimRx billing error
✗Refund requests must be emailed within 28 days of payment; anything later, or sent through another channel, 'will not be honored'. Once your intake is submitted the order is non-refundable
✗The terms describe the opening offer as 'originally priced at $179, currently offered at $199' - the discounted price is higher than the original
✗Headline results (18% average weight loss, 93% 'kept the weight off for good', 6x more than diet and exercise) are footnoted as TrimRx's own patient data over six months, are not published anywhere, and cannot support a claim about keeping weight off permanently
✗Patient counts on a single page range from '10,000+' to 'over 100,000' to '350,000+'
✗The landing page shows a '4.9 Excellent Rating' in five gold stars with no source attached. The one public review platform we could find, Trustpilot, has TrimRx at 3.6 out of 5
✗Urgency devices throughout: a countdown timer, 'Only 9 Spots Left!', and a rotating stack of discounts ($120, $140, $200) that differs by landing page
✗One live funnel still carries a different brand's name ('THE TRINITYMEDS DIFFERENCE'), and the weight-loss calculator renders the placeholder text 'Missing variables: users'
✗No published clinician licence numbers, no live chat, and no insurance billing

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	TrimRx	Signos
Monthly Price	$199	$127
Rating	7.4/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	24/7 support claimed	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Ships within 48 business hours, 1-2 day delivery claimed	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Unlimited messaging and appointments claimed	Continuous glucose data with in-app dietitian support
Money-back Guarantee	Advertised as lose weight or your money back, but the terms allow refunds only for medical disqualification or a billing error, requested in writing within 28 days	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime to stop future charges; processed charges are not refunded and orders are final once your intake is submitted	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose TrimRx if you:

→Want more medication options to choose from
→Value: published tier pricing you can read before you sign up: compounded glp-1 at $174/mo month-to-month, $166 (3-month), $158 (6-month) or $149 (12-month); glp-1 + gip at $279, $266, $258 and $249 (checked july 26, 2026)

Get started with TrimRx

Choose Signos if you:

→Want to save $72/month with a more affordable option
→Prefer a higher-rated service (7.8/10 vs 7.4/10)
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

TrimRx

TrimRx website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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