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Willow vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Willow vs Signos: Overview

Choosing between Willow and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Willow offers both semaglutide and tirzepatide at $299/month with a rating of 7.4/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $172/month is significant - Signos is the more budget-friendly option, while Willow positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$172/mo

Rating Difference

0.4

Winner

Signos

Best For

Budget

Willow

View full Willow review →

Rating

7.4/10

Monthly Price

$299

Medications

semaglutidetirzepatide

Pros

✓Flat published pricing: $299/mo for compounded semaglutide as a weekly injection or a daily tablet, and $399/mo for compounded tirzepatide (checked July 26, 2026)
✓One fee covers the medical evaluation, the medication, unlimited doctor messaging and free discreet shipping, with no separate consultation charge
✓Names its partner pharmacies in its terms - Red Rock Home Pharmacy (Springville, UT), Epiq Pharmacy / Epiq Scripts (Richardson, TX) and The Pharmacy Hub (Miami, FL) - which most compounded GLP-1 sellers do not do
✓Publishes a Florida telehealth provider registration number (TPME1718) and names the exact states it is licensed to serve
✓The 'compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA' disclaimer sits on the homepage itself, not buried in a footer
✓Full refund if you cancel before the prescription is submitted to the pharmacy, processed within 5-10 business days
✓Needle-free daily tablets available for both semaglutide and tirzepatide, and the program is HSA/FSA eligible
✓Same-day prescription review claimed, with support from a named care team

Cons

✗In December 2025 the National Advertising Division found Willow had not substantiated its weight-loss and efficacy claims for compounded semaglutide, Willow declined to comply, and NAD referred it to state attorneys general and ad platforms. That is the most serious independent mark against any provider on this site
✗At $299-$399 a month this is one of the more expensive compounded GLP-1 programs; several competitors advertise $149-$199
✗The flat rate is not locked. The terms state your subscription fee 'may be increased or decreased if your prescription changes, such as by a dosage increase or frequency of refills', so titrating up can raise your bill
✗The site advertises '4.9/5 (2200 + 5 star reviews)' with no source named. Trustpilot, the one public platform we could find, showed 3.8 from 351 reviews on July 26, 2026
✗Cancellation must be received two full calendar days before your next shipping date, or the next order ships and bills
✗The terms tell you to cancel at startwillow.com/contact/ - that URL returned a 404 when we checked, as did the site's /contact and /help-center pages
✗No customer phone number or support email is published anywhere on the public site
✗The published terms are dated November 24, 2021, well before the current product line and pricing
✗Not available nationwide: Willow's terms limit service to 36 states, and this offer in particular is not available in Alabama, Alaska, Arkansas, Delaware, Kansas, Louisiana, Maine, Massachusetts, Mississippi, New Mexico, North Dakota, Rhode Island, South Dakota, Tennessee, Utah, Vermont, West Virginia or Wyoming
✗No insurance billing, and the terms confirm Medicare and Medicaid do not cover the service

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Willow	Signos
Monthly Price	$299	$127
Rating	7.4/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	24/7 online support claimed	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Not published; same-day prescription review claimed	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Unlimited doctor messaging and free follow-ups claimed	Continuous glucose data with in-app dietitian support
Money-back Guarantee	Full refund only if you cancel before the prescription reaches the pharmacy; no returns on medication once dispensed	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime, but the request must arrive two full calendar days before your next shipping date	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Willow if you:

→Want more medication options to choose from
→Value: flat published pricing: $299/mo for compounded semaglutide as a weekly injection or a daily tablet, and $399/mo for compounded tirzepatide (checked july 26, 2026)

Get started with Willow

Choose Signos if you:

→Want to save $172/month with a more affordable option
→Prefer a higher-rated service (7.8/10 vs 7.4/10)
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Willow

Willow website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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