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Yucca Health vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Yucca Health vs Signos: Overview

Choosing between Yucca Health and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Yucca Health offers both semaglutide and tirzepatide at $146/month with a rating of 8/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

With only a $19/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$19/mo

Rating Difference

0.2

Winner

Yucca Health

Best For

Quality

Yucca Health

View full Yucca Health review →

Rating

8/10Better

Monthly Price

$146

Medications

semaglutidetirzepatide

Pros

✓The FAQ publishes actual prices rather than a teaser: semaglutide $146/month and tirzepatide $258/month, with six-month plans at $750 total for semaglutide ($125/mo) and $1,350 for tirzepatide ($225/mo), checked July 27, 2026
✓A lifetime price lock is offered under code YUCCA4LIFE at $146/mo, which if honoured protects against the mid-treatment increases common in this category
✓Trustpilot rating of 4.6 across 1,197 reviews, closely matching the figure shown on site
✓The compounded, not-FDA-approved status is spelled out in full, including the point that these drugs do not undergo FDA review for manufacturing quality
✓The whole site is available in Spanish, which almost no other provider in this category offers
✓Licensed providers in all 50 states, US-licensed pharmacies and free expedited shipping
✓Refund policy and shipping policy are both published as separate documents
✓NAD+ and sermorelin are available if you want more than weight care, without being bundled into the GLP-1 price

Cons

✗A developer's note is rendering inside the live page. Between the product cards the text reads: 'the SSR pass triggers an "Invalid hook call" because the React renderer dispatcher is null in the Cloudflare Workers SSR pipeline'. An engineering comment left in production is not reassuring on a site handling prescriptions
✗Secondary product pricing contradicts itself: NAD+ is shown as 'Starting at $158' in one block and 'As low as $215' in another, and sermorelin as both '$158' and '$199'
✗'Pricing is shared after intake once eligibility is confirmed' sits directly above a FAQ answer that then states all the prices, so the site cannot decide whether pricing is gated
✗Social-proof counters disagree with each other - one product card claims '1000+ Patients enrolled in last 7 days' while others on the same page say '100+'
✗Describing compounded products as having 'the same active pharmaceutical ingredients as brand-name drugs' is the claim type the FDA cited in a February 2026 warning letter to a competitor, even though Yucca does disclaim FDA approval immediately afterwards
✗The 'for life' price lock has no published terms explaining what would void it
✗No published phone number or support hours
✗No BBB profile or complaint record to check against the Trustpilot score

Choose Yucca Health

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	Yucca Health	Signos
Monthly Price	$146	$127
Rating	8/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free expedited shipping claimed	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Not published	Continuous glucose data with in-app dietitian support
Money-back Guarantee	A refund policy is published as a separate document; no blanket money-back guarantee is advertised	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Published separately; the lifetime price lock has no stated conditions	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose Yucca Health if you:

→Prefer a higher-rated service (8/10 vs 7.8/10)
→Want more medication options to choose from
→Value: the faq publishes actual prices rather than a teaser: semaglutide $146/month and tirzepatide $258/month, with six-month plans at $750 total for semaglutide ($125/mo) and $1,350 for tirzepatide ($225/mo), checked july 27, 2026

Get started with Yucca Health

Choose Signos if you:

→Want to save $19/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

Yucca Health

Yucca Health website

Signos

Signos website

Our recommendation

Yucca Health comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Yucca Health

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