← All providers

Enhance MD vs TMates

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Enhance MD vs TMates: Overview

Choosing between Enhance MD and TMates for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Enhance MD offers both semaglutide and tirzepatide at $212/month with a rating of 7.7/10. TMates also provides both semaglutide and tirzepatide at $249/month with a 7.8/10 rating.

With only a $37/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$37/mo

Rating Difference

0.1

Winner

TMates

Best For

Quality

Enhance MD

View full Enhance MD review →

Rating

7.7/10

Monthly Price

$212Cheaper

Medications

semaglutidetirzepatide

Pros

✓One price at every dose, stated as 'One consistent price from your first dose to your last', so titrating up never raises the bill
✓Full tier pricing is published: GLP-1 Core (semaglutide) $112 first month then $212/mo, Advanced (tirzepatide) $180 then $280/mo, and microdosing tirzepatide at $169/mo (checked July 27, 2026)
✓The compounded, not-FDA-approved disclosure is unambiguous and placed next to the products rather than in a footer
✓Product images are labelled 'Not actual vial - For marketing purposes only'
✓The microdosing option is framed honestly, stating it suits patients seeking longevity benefits and that 'weight loss may occur, but isn't the primary aim' rather than overselling it
✓Medication ships quarterly, so there are fewer delivery events to manage
✓Discount codes and their terms are stated plainly - $100 off 3+ month plans, $50 off monthly

Cons

✗Enhance MD sells a combined semaglutide plus tirzepatide product, marketed as 'GLP-1 Elite' at $322/month. No published clinical trial evaluates taking these two medicines together; both act on the GLP-1 receptor, so stacking them plausibly compounds gastrointestinal side effects without established additional benefit. Anyone considering it should discuss the evidence base with an independent clinician first
✗The '100% Money-back guarantee' is not a money-back guarantee. Its own wording limits it to onboarding: 'If at any point during the onboarding process your provider finds you ineligible for medication, Enhance.MD will provide a refund.' Once you are prescribed, it does not apply
✗First-month pricing nearly doubles at renewal - $112 becomes $212 for semaglutide and $180 becomes $280 for tirzepatide
✗Trustpilot carries 159 reviews against a claim of 10,000+ patients transformed
✗This offer is not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia - eleven states
✗No published customer phone number or support hours
✗No BBB profile or independent complaint record to check
✗Quarterly shipping means committing to a longer supply of a medication you may not tolerate

Choose Enhance MD

TMates

View full TMates review →

Rating

7.8/10Better

Monthly Price

$249

Medications

semaglutidetirzepatide

Pros

✓Both price ladders are published in full and the arithmetic is correct at every tier. Semaglutide runs $249 for one month, $217/mo over three ($650), $175/mo over six ($1,050) and $158/mo over twelve ($1,900), checked July 27, 2026
✓Tirzepatide is laid out the same way: $297 monthly, $267/mo over three ($800), $217/mo over six ($1,299) and $167/mo over twelve ($1,999)
✓Every advertised saving checks out - the 13%, 30%, 37%, 10%, 27% and 44% figures all match the underlying numbers
✓One price across all doses, from 0.25mg to 2.4mg semaglutide and 2.5mg to 15mg tirzepatide, so titrating up never costs more
✓Possible side effects are listed openly on the product page - nausea, injection site reactions, decreased appetite and gastrointestinal discomfort - with a note that most are mild and temporary
✓Both injectable and oral formats are offered at the same published prices
✓Medication, provider review, personalised dosing and ongoing support are all included in the price, with free shipping and cancel-anytime terms

Cons

✗We could not find an explicit statement that the compounded medications are not FDA-approved. The site explains what compounding is but omits the disclosure nearly every competitor makes
✗Trustpilot has exactly one review of this domain, so there is effectively no independent evidence about the service against a claim of 2,400+ patients
✗Tirzepatide is billed as the 'Most powerful GLP-1 medication available' - a superiority claim made about a compounded preparation that has not been trialled against anything
✗The 'up to 15% of their body weight in a year' figure is presented as what TMates has seen in its own patients, with no published data behind it
✗The lowest advertised rates require paying for a full year upfront - $1,900 for semaglutide or $1,999 for tirzepatide
✗The site is behind bot protection and will not load without JavaScript, so pricing is invisible to anyone browsing with scripts disabled
✗No published customer phone number, support email or support hours
✗No BBB profile or complaint record to check

Feature-by-feature comparison

Feature	Enhance MD	TMates
Monthly Price	$212	$249
Rating	7.7/10	7.8/10
Medications	semaglutide, tirzepatide	semaglutide, tirzepatide
Insurance Accepted	No	No
Support Hours	Not published	Not published
Live Chat	No	No
Free Shipping	Yes	Yes
Shipping Speed	Medication shipped every 12 weeks	Free shipping; timeframe not published
Mobile App	No	No
Dedicated Coach	Not included	Not included
Follow-up Frequency	Ongoing provider care and support included	Ongoing provider support included
Money-back Guarantee	Advertised as a 100% money-back guarantee, but it only covers being found ineligible during onboarding	None published
Cancellation Policy	Plans run monthly or in 3+ month blocks; no separate cancellation policy published	Cancel anytime, but multi-month plans are paid upfront

Which should you choose?

Choose Enhance MD if you:

→Want to save $37/month with a more affordable option
→Value: one price at every dose, stated as 'one consistent price from your first dose to your last', so titrating up never raises the bill

Get started with Enhance MD

Choose TMates if you:

→Prefer a higher-rated service (7.8/10 vs 7.7/10)
→Value: both price ladders are published in full and the arithmetic is correct at every tier. semaglutide runs $249 for one month, $217/mo over three ($650), $175/mo over six ($1,050) and $158/mo over twelve ($1,900), checked july 27, 2026

Get started with TMates

Website previews

Enhance MD

Enhance MD website

TMates

TMates website

Our recommendation

TMates comes out ahead with a higher rating of 7.8/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with TMates

Related comparisons

Enhance MD vs CoreAge Rx

Enhance MD vs Zepbound

Enhance MD vs Mounjaro

Enhance MD vs Wegovy Pill

Enhance MD vs Foundayo

Enhance MD vs Wegovy

Enhance MD vs NovoCare Pharmacy

Enhance MD vs Ozempic

Enhance MD vs Form Health

Enhance MD vs Henry Meds

Enhance MD vs Sesame Care

Enhance MD vs FuturHealth

Enhance MD vs Circle Medical

Enhance MD vs Ro

Enhance MD vs Midi Health

Enhance MD vs Noom Med

Enhance MD vs Precision Telemed

Enhance MD vs Hims

Enhance MD vs Calibrate

Enhance MD vs PlushCare

Compare other providers

Compare GLP-1 Brands

First Brand

vs

Second Brand