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LifeMD vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

LifeMD vs Signos: Overview

Choosing between LifeMD and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

LifeMD offers both semaglutide and tirzepatide at $199/month with a rating of 8.5/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $72/month is significant - Signos is the more budget-friendly option, while LifeMD positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$72/mo

Rating Difference

0.7

Winner

LifeMD

Best For

Quality

LifeMD

View full LifeMD review →

Rating

8.5/10Better

Monthly Price

$199

Medications

semaglutidetirzepatide

Pros

✓Prescribes FDA-approved branded GLP-1s - Zepbound and Wegovy - rather than compounded preparations, so you get the exact product the trials studied
✓Accepts insurance including Medicare, and advertises as low as $0 copay for branded GLP-1s where coverage applies
✓Publishes cash prices too: Wegovy Pen from $199/month and Zepbound Vial from $349/month (checked July 28, 2026)
✓Offers an outcome-based guarantee: 'lose 10% of your weight or your money back', which ties the promise to a result rather than a satisfaction survey
✓HSA and FSA eligible
✓Weight care sits inside a full telehealth service, so urgent care, labs and other specialties are available under the same account

Cons

✗The rotating banner on the weight-management page shows the Wegovy Pen at both '$199' and '$499' in the same carousel, which makes the real starting price unclear before you sign up
✗The money-back guarantee carries a footnote marker on site, so read the qualifying conditions before relying on it
✗Insurance coverage for obesity medication is patchy, so the '$0 copay' outcome will not apply to many people and the cash prices are what you should plan around
✗A 4.0 Trustpilot average is mid-range for this category
✗Branded GLP-1s at $199-$349/month are more expensive than compounded alternatives, which is the trade-off for using an FDA-approved product
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	LifeMD	Signos
Monthly Price	$199	$127
Rating	8.5/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	Yes	No
Support Hours	Mon-Fri 8AM-8PM ET	In-app dietitian chat; hours not published
Live Chat	Available	Available
Free Shipping	Yes	Yes
Shipping Speed	3-5 days	Free shipping; six-month plans ship in three-month bundles
Mobile App	Available	Available
Dedicated Coach	Not included	Included
Follow-up Frequency	Quarterly	Continuous glucose data with in-app dietitian support
Money-back Guarantee	Lose 10% of your weight or your money back (conditions apply)	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel anytime	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose LifeMD if you:

→Prefer a higher-rated service (8.5/10 vs 7.8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Value: prescribes fda-approved branded glp-1s - zepbound and wegovy - rather than compounded preparations, so you get the exact product the trials studied

Get started with LifeMD

Choose Signos if you:

→Want to save $72/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

LifeMD

LifeMD website

Signos

Signos website

Our recommendation

LifeMD comes out ahead with a higher rating of 8.5/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with LifeMD

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