PlushCare vs Sesame Care
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
PlushCare vs Sesame Care: Overview
Choosing between PlushCare and Sesame Care for GLP-1 weight loss medication? Both are highly-rated providers, but they differ in pricing, medication options, and service features.
PlushCare offers both semaglutide and tirzepatide at $20/month with a rating of 8.5/10. Sesame Care also provides both semaglutide and tirzepatide at $59/month with a 8.7/10 rating.
With only a $39/month price difference, your choice will likely come down to features, support quality, and medication options.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$39/mo
Rating Difference
0.2
Winner
Sesame Care
Best For
Quality
PlushCare
View full PlushCare review →Rating
8.5/10
Monthly Price
$20Cheaper
Medications
semaglutidetirzepatideliraglutide
Pros
- ✓Accepts insurance, which almost nothing else on this site does. Most in-network patients pay a copay of $30 or less for a visit
- ✓Membership is $19.99/month with the first month free, and there is no minimum commitment
- ✓Prescribes only FDA-approved medications - Zepbound, Wegovy, Saxenda, Contrave and Xenical - so no compounded product is involved
- ✓Care comes from board-certified primary care physicians rather than an asynchronous questionnaire review
- ✓A full refund is offered if the doctor is unable to treat you
- ✓Membership includes far more than weight care: 24/7 urgent care video visits, mental health support, discounted lab tests and free memberships for family
- ✓An in-app prescription discount card and HSA/FSA eligibility can reduce medication costs further
- ✓The site is candid that GLP-1s 'usually cost about $1000 per month out of pocket' and advises checking insurance coverage first, rather than hiding the real figure
Cons
- ✗The $19.99 membership buys access, not medication. Without insurance coverage the GLP-1 itself can run about $1,000 a month, which PlushCare states openly but which makes the headline price misleading if read as a treatment cost
- ✗Visits are charged on top of membership - $129 for an initial visit without in-network insurance
- ✗Trustpilot sits at 3.4 out of 5 across 2,735 reviews, the weakest score of any established provider we have reviewed here
- ✗Prescriptions are explicitly at the doctor's discretion, so paying for membership and a visit does not guarantee you leave with a GLP-1
- ✗This is a general telehealth service, so the weight-loss programme has less dedicated structure - no built-in coaching, food tracking or dose-titration support
- ✗Medication and lab costs are excluded from every advertised price, so your real monthly outlay depends entirely on your insurer
- ✗Contrave is offered as a $99 cash-pay alternative, but the cash cost of the GLP-1s themselves is not published
- ✗If you have no insurance and want a GLP-1, this route is likely to cost far more than the compounded providers listed elsewhere on this site
Sesame Care
View full Sesame Care review →Rating
8.7/10Better
Monthly Price
$59
Medications
semaglutidetirzepatideorforglipron
Pros
- ✓Publishes cash prices dose by dose, which no other provider on this site does. Zepbound KwikPen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
- ✓The same detail applies across the range: Wegovy pill $149/mo (1.5mg, 4mg) or $299 (9mg, 25mg); Wegovy pen $199 for the first two months for new patients then $349; Foundayo from $149 to $349 depending on dose (checked July 27, 2026)
- ✓Every medication offered is FDA-approved and branded - no compounded product is involved
- ✓Insurance is accepted, and with coverage medication can drop to as low as $25/mo
- ✓The care programme itself - video visits, dedicated provider, labs and messaging - starts at $59/mo
- ✓Efficacy milestones are properly sourced, citing a study of injectable semaglutide 2.4mg with the population spelled out (BMI 30+, or 27+ with a weight-related condition, non-diabetic) and paired with lifestyle change
- ✓A full refund is available if you cancel at least three hours before your first visit
- ✓The wider marketplace lets you compare individual providers on price, with appointments from $37
Cons
- ✗The $59/mo headline depends on a 12-month 'Success by Sesame' commitment, and the annual fee is explicitly non-refundable once paid - cancel in month two and you do not get the remaining ten months back
- ✗Medication costs are not included in the programme price, which Sesame states plainly but which means the real monthly outlay is the subscription plus the drug
- ✗Cash prices escalate steeply with dose. Zepbound more than doubles from $299 to $698 as you titrate to a maintenance dose, so the entry price is not the price you will end up paying
- ✗The Wegovy pen intro rate of $199 applies to new patients only and for two months, after which it is $349
- ✗Monthly subscribers are not refunded for months already paid, even if unused
- ✗Because pricing depends on insurance status, pharmacy and dose, there is no single figure you can plan around before signing up
- ✗This is a general healthcare marketplace, so the weight-loss programme sits alongside urgent care and prescription refills rather than being a dedicated speciality service
Feature-by-feature comparison
| Feature | PlushCare | Sesame Care |
|---|---|---|
| Monthly Price | $20 | $59 |
| Rating | 8.5/10 | 8.7/10 |
| Medications | semaglutide, tirzepatide, liraglutide | semaglutide, tirzepatide, orforglipron |
| Insurance Accepted | Yes | Yes |
| Support Hours | Video visits available 24/7 | Not published |
| Live Chat | No | No |
| Free Shipping | No | No |
| Shipping Speed | Filled at your pharmacy; not shipped by PlushCare | Filled at your pharmacy; not shipped by Sesame |
| Mobile App | Available | Available |
| Dedicated Coach | Not included | Included |
| Follow-up Frequency | Ongoing management with a board-certified primary care physician | Ongoing video visits, labs and messaging with a dedicated provider |
| Money-back Guarantee | Full refund if the doctor is unable to treat you; medication and lab costs are never included | Full refund if you cancel at least 3 hours before your first visit; annual fees are non-refundable once paid |
| Cancellation Policy | Cancel anytime, no minimum commitment; first month of membership is free | Self-cancel monthly or annual subscriptions any time, but past months and annual fees are not refunded |
Which should you choose?
Choose PlushCare if you:
- →Want to save $39/month with a more affordable option
- →Value: accepts insurance, which almost nothing else on this site does. most in-network patients pay a copay of $30 or less for a visit
Choose Sesame Care if you:
- →Prefer a higher-rated service (8.7/10 vs 8.5/10)
- →Want personalized coaching support included
- →Value: publishes cash prices dose by dose, which no other provider on this site does. zepbound kwikpen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
Website previews
PlushCare
Sesame Care
Our recommendation
Sesame Care comes out ahead with a higher rating of 8.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.
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