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RxSpan MD vs Enhance MD

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

RxSpan MD vs Enhance MD: Overview

Choosing between RxSpan MD and Enhance MD for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

RxSpan MD offers both semaglutide and tirzepatide at $249/month with a rating of 7.6/10. Enhance MD also provides both semaglutide and tirzepatide at $212/month with a 7.7/10 rating.

With only a $37/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$37/mo

Rating Difference

0.1

Winner

Enhance MD

Best For

Budget

RxSpan MD

View full RxSpan MD review →

Rating

7.6/10

Monthly Price

$249

Medications

semaglutidetirzepatide

Pros

✓A full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked July 27, 2026)
✓Brand-name options are offered and priced openly too - Ozempic $1,299, Wegovy $1,349 and Zepbound $1,069
✓The plan ladder is shown with each rate: $249/mo monthly, $219/mo on 3 months, $199/mo on 6 months and $194/mo on 12 months
✓The price is stated to include the consult, medication, supplies, shipping and support, with no separate membership fee
✓Oral capsule versions of both semaglutide and tirzepatide are available for people who do not want injections
✓Plans can be cancelled or changed at any time
✓The site states plainly that 'Prescription is not guaranteed' rather than implying approval is automatic
✓A named, credentialled physician is associated with the service rather than an anonymous 'medical team'

Cons

✗Every headline price is labelled 'For the first month'. What you pay from month two is not shown anywhere on the product screen, so the ongoing cost is unknown until you are further into the funnel
✗You pay at checkout before a provider reviews your case - the site confirms 'After checkout, a provider will review your information to determine if treatment is right for you' - so your money goes first and eligibility is decided afterwards
✗There is no independent review signal at all: no Trustpilot profile, no BBB file, and no rating displayed on site
✗Brand-name pricing is far above the manufacturers' own direct-pay programmes - $1,349 for Wegovy and $1,069 for Zepbound against considerably cheaper NovoCare and LillyDirect routes
✗No customer phone number is published; the only contact is an email address
✗The supervising physician's board certification is in plastic surgery, not obesity medicine, endocrinology or internal medicine
✗The banner copy - 'No Hidden Fees', 'Free, Expedited Delivery', 'Doctor-led Plans & Coaching' - is word-for-word identical to TrimRx's, indicating a shared white-label funnel rather than an independently built service
✗Product prices only render once JavaScript loads; with scripts blocked the weight-loss category reads 'No products found for Weight Loss'

Choose RxSpan MD

Enhance MD

View full Enhance MD review →

Rating

7.7/10Better

Monthly Price

$212Cheaper

Medications

semaglutidetirzepatide

Pros

✓One price at every dose, stated as 'One consistent price from your first dose to your last', so titrating up never raises the bill
✓Full tier pricing is published: GLP-1 Core (semaglutide) $112 first month then $212/mo, Advanced (tirzepatide) $180 then $280/mo, and microdosing tirzepatide at $169/mo (checked July 27, 2026)
✓The compounded, not-FDA-approved disclosure is unambiguous and placed next to the products rather than in a footer
✓Product images are labelled 'Not actual vial - For marketing purposes only'
✓The microdosing option is framed honestly, stating it suits patients seeking longevity benefits and that 'weight loss may occur, but isn't the primary aim' rather than overselling it
✓Medication ships quarterly, so there are fewer delivery events to manage
✓Discount codes and their terms are stated plainly - $100 off 3+ month plans, $50 off monthly

Cons

✗Enhance MD sells a combined semaglutide plus tirzepatide product, marketed as 'GLP-1 Elite' at $322/month. No published clinical trial evaluates taking these two medicines together; both act on the GLP-1 receptor, so stacking them plausibly compounds gastrointestinal side effects without established additional benefit. Anyone considering it should discuss the evidence base with an independent clinician first
✗The '100% Money-back guarantee' is not a money-back guarantee. Its own wording limits it to onboarding: 'If at any point during the onboarding process your provider finds you ineligible for medication, Enhance.MD will provide a refund.' Once you are prescribed, it does not apply
✗First-month pricing nearly doubles at renewal - $112 becomes $212 for semaglutide and $180 becomes $280 for tirzepatide
✗Trustpilot carries 159 reviews against a claim of 10,000+ patients transformed
✗This offer is not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia - eleven states
✗No published customer phone number or support hours
✗No BBB profile or independent complaint record to check
✗Quarterly shipping means committing to a longer supply of a medication you may not tolerate

Choose Enhance MD

Feature-by-feature comparison

Feature	RxSpan MD	Enhance MD
Monthly Price	$249	$212
Rating	7.6/10	7.7/10
Medications	semaglutide, tirzepatide	semaglutide, tirzepatide
Insurance Accepted	No	No
Support Hours	Not published	Not published
Live Chat	No	No
Free Shipping	Yes	Yes
Shipping Speed	Free expedited delivery claimed; timeframe not published	Medication shipped every 12 weeks
Mobile App	No	No
Dedicated Coach	Included	Not included
Follow-up Frequency	Doctor-led plans and coaching advertised; frequency not published	Ongoing provider care and support included
Money-back Guarantee	None published; you are charged at checkout before a provider decides whether to prescribe	Advertised as a 100% money-back guarantee, but it only covers being found ineligible during onboarding
Cancellation Policy	Cancel or change plans at any time	Plans run monthly or in 3+ month blocks; no separate cancellation policy published

Which should you choose?

Choose RxSpan MD if you:

→Want personalized coaching support included
→Value: a full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked july 27, 2026)

Get started with RxSpan MD

Choose Enhance MD if you:

→Want to save $37/month with a more affordable option
→Prefer a higher-rated service (7.7/10 vs 7.6/10)
→Value: one price at every dose, stated as 'one consistent price from your first dose to your last', so titrating up never raises the bill

Get started with Enhance MD

Website previews

RxSpan MD

RxSpan MD website

Enhance MD

Enhance MD website

Our recommendation

Enhance MD comes out ahead with a higher rating of 7.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Enhance MD

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