RxSpan MD vs Shameless Care
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
RxSpan MD vs Shameless Care: Overview
Choosing between RxSpan MD and Shameless Care for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
RxSpan MD offers both semaglutide and tirzepatide at $249/month with a rating of 7.6/10. Shameless Care also provides both semaglutide and tirzepatide at $109/month with a 8/10 rating.
The price difference of $140/month is significant - Shameless Care is the more budget-friendly option, while RxSpan MD positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$140/mo
Rating Difference
0.4
Winner
Shameless Care
Best For
Budget
RxSpan MD
View full RxSpan MD review →Rating
7.6/10
Monthly Price
$249
Medications
semaglutidetirzepatide
Pros
- ✓A full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked July 27, 2026)
- ✓Brand-name options are offered and priced openly too - Ozempic $1,299, Wegovy $1,349 and Zepbound $1,069
- ✓The plan ladder is shown with each rate: $249/mo monthly, $219/mo on 3 months, $199/mo on 6 months and $194/mo on 12 months
- ✓The price is stated to include the consult, medication, supplies, shipping and support, with no separate membership fee
- ✓Oral capsule versions of both semaglutide and tirzepatide are available for people who do not want injections
- ✓Plans can be cancelled or changed at any time
- ✓The site states plainly that 'Prescription is not guaranteed' rather than implying approval is automatic
- ✓A named, credentialled physician is associated with the service rather than an anonymous 'medical team'
Cons
- ✗Every headline price is labelled 'For the first month'. What you pay from month two is not shown anywhere on the product screen, so the ongoing cost is unknown until you are further into the funnel
- ✗You pay at checkout before a provider reviews your case - the site confirms 'After checkout, a provider will review your information to determine if treatment is right for you' - so your money goes first and eligibility is decided afterwards
- ✗There is no independent review signal at all: no Trustpilot profile, no BBB file, and no rating displayed on site
- ✗Brand-name pricing is far above the manufacturers' own direct-pay programmes - $1,349 for Wegovy and $1,069 for Zepbound against considerably cheaper NovoCare and LillyDirect routes
- ✗No customer phone number is published; the only contact is an email address
- ✗The supervising physician's board certification is in plastic surgery, not obesity medicine, endocrinology or internal medicine
- ✗The banner copy - 'No Hidden Fees', 'Free, Expedited Delivery', 'Doctor-led Plans & Coaching' - is word-for-word identical to TrimRx's, indicating a shared white-label funnel rather than an independently built service
- ✗Product prices only render once JavaScript loads; with scripts blocked the weight-loss category reads 'No products found for Weight Loss'
Shameless Care
View full Shameless Care review →Rating
8/10Better
Monthly Price
$109Cheaper
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
Feature-by-feature comparison
| Feature | RxSpan MD | Shameless Care |
|---|---|---|
| Monthly Price | $249 | $109 |
| Rating | 7.6/10 | 8/10 |
| Medications | semaglutide, tirzepatide | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline |
| Insurance Accepted | No | No |
| Support Hours | Not published | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Free expedited delivery claimed; timeframe not published | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost |
| Mobile App | No | No |
| Dedicated Coach | Included | Not included |
| Follow-up Frequency | Doctor-led plans and coaching advertised; frequency not published | Board-certified physician assigned from start to finish; ongoing cadence not published |
| Money-back Guarantee | None published; you are charged at checkout before a provider decides whether to prescribe | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published |
| Cancellation Policy | Cancel or change plans at any time | No subscriptions - every purchase is one-off, so there is nothing to cancel |
Which should you choose?
Choose RxSpan MD if you:
- →Want personalized coaching support included
- →Value: a full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked july 27, 2026)
Choose Shameless Care if you:
- →Want to save $140/month with a more affordable option
- →Prefer a higher-rated service (8/10 vs 7.6/10)
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Website previews
RxSpan MD
Shameless Care
Our recommendation
Shameless Care comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.
Get started with Shameless CareRelated comparisons
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