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RxSpan MD vs Signos

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

RxSpan MD vs Signos: Overview

Choosing between RxSpan MD and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

RxSpan MD offers both semaglutide and tirzepatide at $249/month with a rating of 7.6/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.

The price difference of $122/month is significant - Signos is the more budget-friendly option, while RxSpan MD positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$122/mo

Rating Difference

0.2

Winner

Signos

Best For

Budget

RxSpan MD

View full RxSpan MD review →

Rating

7.6/10

Monthly Price

$249

Medications

semaglutidetirzepatide

Pros

✓A full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked July 27, 2026)
✓Brand-name options are offered and priced openly too - Ozempic $1,299, Wegovy $1,349 and Zepbound $1,069
✓The plan ladder is shown with each rate: $249/mo monthly, $219/mo on 3 months, $199/mo on 6 months and $194/mo on 12 months
✓The price is stated to include the consult, medication, supplies, shipping and support, with no separate membership fee
✓Oral capsule versions of both semaglutide and tirzepatide are available for people who do not want injections
✓Plans can be cancelled or changed at any time
✓The site states plainly that 'Prescription is not guaranteed' rather than implying approval is automatic
✓A named, credentialled physician is associated with the service rather than an anonymous 'medical team'

Cons

✗Every headline price is labelled 'For the first month'. What you pay from month two is not shown anywhere on the product screen, so the ongoing cost is unknown until you are further into the funnel
✗You pay at checkout before a provider reviews your case - the site confirms 'After checkout, a provider will review your information to determine if treatment is right for you' - so your money goes first and eligibility is decided afterwards
✗There is no independent review signal at all: no Trustpilot profile, no BBB file, and no rating displayed on site
✗Brand-name pricing is far above the manufacturers' own direct-pay programmes - $1,349 for Wegovy and $1,069 for Zepbound against considerably cheaper NovoCare and LillyDirect routes
✗No customer phone number is published; the only contact is an email address
✗The supervising physician's board certification is in plastic surgery, not obesity medicine, endocrinology or internal medicine
✗The banner copy - 'No Hidden Fees', 'Free, Expedited Delivery', 'Doctor-led Plans & Coaching' - is word-for-word identical to TrimRx's, indicating a shared white-label funnel rather than an independently built service
✗Product prices only render once JavaScript loads; with scripts blocked the weight-loss category reads 'No products found for Weight Loss'

Choose RxSpan MD

Signos

View full Signos review →

Rating

7.8/10Better

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Feature-by-feature comparison

Feature	RxSpan MD	Signos
Monthly Price	$249	$127
Rating	7.6/10	7.8/10
Medications	semaglutide, tirzepatide	continuous glucose monitoring
Insurance Accepted	No	No
Support Hours	Not published	In-app dietitian chat; hours not published
Live Chat	No	Available
Free Shipping	Yes	Yes
Shipping Speed	Free expedited delivery claimed; timeframe not published	Free shipping; six-month plans ship in three-month bundles
Mobile App	No	Available
Dedicated Coach	Included	Included
Follow-up Frequency	Doctor-led plans and coaching advertised; frequency not published	Continuous glucose data with in-app dietitian support
Money-back Guarantee	None published; you are charged at checkout before a provider decides whether to prescribe	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)
Cancellation Policy	Cancel or change plans at any time	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused

Which should you choose?

Choose RxSpan MD if you:

→Want more medication options to choose from
→Value: a full product price list is published rather than a single teaser figure: semaglutide injection $249, tirzepatide injection $329, semaglutide capsules $249 and tirzepatide capsules $349 for the first month (checked july 27, 2026)

Get started with RxSpan MD

Choose Signos if you:

→Want to save $122/month with a more affordable option
→Prefer a higher-rated service (7.8/10 vs 7.6/10)
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Website previews

RxSpan MD

RxSpan MD website

Signos

Signos website

Our recommendation

Signos comes out ahead with a higher rating of 7.8/10.

Get started with Signos

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