← All providers

Sesame Care vs Direct Meds

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Sesame Care vs Direct Meds: Overview

Choosing between Sesame Care and Direct Meds for GLP-1 weight loss medication? Both are highly-rated providers, but they differ in pricing, medication options, and service features.

Sesame Care offers both semaglutide and tirzepatide at $59/month with a rating of 8.7/10. Direct Meds also provides both semaglutide and tirzepatide at $297/month with a 8/10 rating.

The price difference of $238/month is significant - Sesame Care is the more budget-friendly option, while Direct Meds positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$238/mo

Rating Difference

0.7

Winner

Sesame Care

Best For

Budget

Sesame Care

View full Sesame Care review →

Rating

8.7/10Better

Monthly Price

$59Cheaper

Medications

semaglutidetirzepatideorforglipron

Pros

✓Publishes cash prices dose by dose, which no other provider on this site does. Zepbound KwikPen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
✓The same detail applies across the range: Wegovy pill $149/mo (1.5mg, 4mg) or $299 (9mg, 25mg); Wegovy pen $199 for the first two months for new patients then $349; Foundayo from $149 to $349 depending on dose (checked July 27, 2026)
✓Every medication offered is FDA-approved and branded - no compounded product is involved
✓Insurance is accepted, and with coverage medication can drop to as low as $25/mo
✓The care programme itself - video visits, dedicated provider, labs and messaging - starts at $59/mo
✓Efficacy milestones are properly sourced, citing a study of injectable semaglutide 2.4mg with the population spelled out (BMI 30+, or 27+ with a weight-related condition, non-diabetic) and paired with lifestyle change
✓A full refund is available if you cancel at least three hours before your first visit
✓The wider marketplace lets you compare individual providers on price, with appointments from $37

Cons

✗The $59/mo headline depends on a 12-month 'Success by Sesame' commitment, and the annual fee is explicitly non-refundable once paid - cancel in month two and you do not get the remaining ten months back
✗Medication costs are not included in the programme price, which Sesame states plainly but which means the real monthly outlay is the subscription plus the drug
✗Cash prices escalate steeply with dose. Zepbound more than doubles from $299 to $698 as you titrate to a maintenance dose, so the entry price is not the price you will end up paying
✗The Wegovy pen intro rate of $199 applies to new patients only and for two months, after which it is $349
✗Monthly subscribers are not refunded for months already paid, even if unused
✗Because pricing depends on insurance status, pharmacy and dose, there is no single figure you can plan around before signing up
✗This is a general healthcare marketplace, so the weight-loss programme sits alongside urgent care and prescription refills rather than being a dedicated speciality service

Choose Sesame Care

Direct Meds

View full Direct Meds review →

Rating

8/10

Monthly Price

$297

Medications

semaglutidetirzepatide

Pros

✓The compounding explanation is genuinely educational, citing USP 795 and USP 797 and identifying the pharmacy as a 503A facility rather than hand-waving about 'FDA-registered' status
✓Trustpilot rating of 4.6 from 12,750 reviews, a large and credible independent sample
✓The FAQ states flat monthly prices with no membership layered on: $297/month for semaglutide and $399/month for tirzepatide (checked July 27, 2026)
✓That price is stated to include the medication, doctor visits normally billed at $99 each, next-day FedEx or UPS shipping, and all injection supplies
✓Same price at every dose, so titrating up does not increase the bill
✓A full refund is given if your prescription is not approved
✓A published customer phone number, 888-696-7176, which most competitors do not offer
✓This offer is restricted in only one state, Arkansas

Cons

✗The headline price and the real price do not match. The landing page leads with 'Starting at $147' while the FAQ on the same site states 'For Semaglutide we charge $297/month. For Tirzepatide we charge $399/month' - roughly double
✗Discounts are advertised in three different sizes on one page: '$150 Off Today', 'Up to $200 OFF' and 'Get $150 OFF your prescription instantly', with no terms attached to any of them
✗The 'patient satisfaction guarantee' is undefined - 'If you are unhappy with your results, let us know and we'll make it right' commits to nothing specific
✗The landing page uses the same template as several other compounded GLP-1 funnels, down to the identical headline 'The proven way to lose 15% of your body weight fast!'
✗'We've been featured all over' appears with no named publications or links
✗The '15% of your body weight' figure comes from trials of the branded drugs, not from Direct Meds' compounded product or its own patients
✗No BBB profile could be found to set against the Trustpilot score
✗Support hours are not published, only the phone number and an email address

Choose Direct Meds

Feature-by-feature comparison

Feature	Sesame Care	Direct Meds
Monthly Price	$59	$297
Rating	8.7/10	8/10
Medications	semaglutide, tirzepatide, orforglipron	semaglutide, tirzepatide
Insurance Accepted	Yes	No
Support Hours	Not published	Not published
Live Chat	No	Available
Free Shipping	No	Yes
Shipping Speed	Filled at your pharmacy; not shipped by Sesame	Next-day FedEx or UPS; arrives in 1-2 days
Mobile App	Available	No
Dedicated Coach	Included	Not included
Follow-up Frequency	Ongoing video visits, labs and messaging with a dedicated provider	1:1 medical support with messaging and refills
Money-back Guarantee	Full refund if you cancel at least 3 hours before your first visit; annual fees are non-refundable once paid	Full refund if your prescription is not approved; a vaguely worded satisfaction guarantee otherwise
Cancellation Policy	Self-cancel monthly or annual subscriptions any time, but past months and annual fees are not refunded	Cancel anytime, no monthly membership

Which should you choose?

Choose Sesame Care if you:

→Want to save $238/month with a more affordable option
→Prefer a higher-rated service (8.7/10 vs 8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Want personalized coaching support included
→Value: publishes cash prices dose by dose, which no other provider on this site does. zepbound kwikpen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start

Get started with Sesame Care

Choose Direct Meds if you:

→Value: the compounding explanation is genuinely educational, citing usp 795 and usp 797 and identifying the pharmacy as a 503a facility rather than hand-waving about 'fda-registered' status

Get started with Direct Meds

Website previews

Sesame Care

Sesame Care website

Direct Meds

Direct Meds website

Our recommendation

Sesame Care comes out ahead with a higher rating of 8.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Sesame Care

Related comparisons

Sesame Care vs CoreAge Rx

Sesame Care vs Zepbound

Sesame Care vs Mounjaro

Sesame Care vs Wegovy Pill

Sesame Care vs Foundayo

Sesame Care vs Wegovy

Sesame Care vs NovoCare Pharmacy

Sesame Care vs Ozempic

Sesame Care vs Form Health

Sesame Care vs Henry Meds

Sesame Care vs FuturHealth

Sesame Care vs Circle Medical

Sesame Care vs Ro

Sesame Care vs Midi Health

Sesame Care vs Noom Med

Sesame Care vs Precision Telemed

Sesame Care vs Hims

Sesame Care vs Calibrate

Sesame Care vs PlushCare

Sesame Care vs LifeMD

Compare other providers

Compare GLP-1 Brands

First Brand

vs

Second Brand