Sesame Care vs Signos
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Sesame Care vs Signos: Overview
Choosing between Sesame Care and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
Sesame Care offers both semaglutide and tirzepatide at $59/month with a rating of 8.7/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.
The price difference of $68/month is significant - Sesame Care is the more budget-friendly option, while Signos positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$68/mo
Rating Difference
0.9
Winner
Sesame Care
Best For
Budget
Sesame Care
View full Sesame Care review →Rating
8.7/10Better
Monthly Price
$59Cheaper
Medications
semaglutidetirzepatideorforglipron
Pros
- ✓Publishes cash prices dose by dose, which no other provider on this site does. Zepbound KwikPen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
- ✓The same detail applies across the range: Wegovy pill $149/mo (1.5mg, 4mg) or $299 (9mg, 25mg); Wegovy pen $199 for the first two months for new patients then $349; Foundayo from $149 to $349 depending on dose (checked July 27, 2026)
- ✓Every medication offered is FDA-approved and branded - no compounded product is involved
- ✓Insurance is accepted, and with coverage medication can drop to as low as $25/mo
- ✓The care programme itself - video visits, dedicated provider, labs and messaging - starts at $59/mo
- ✓Efficacy milestones are properly sourced, citing a study of injectable semaglutide 2.4mg with the population spelled out (BMI 30+, or 27+ with a weight-related condition, non-diabetic) and paired with lifestyle change
- ✓A full refund is available if you cancel at least three hours before your first visit
- ✓The wider marketplace lets you compare individual providers on price, with appointments from $37
Cons
- ✗The $59/mo headline depends on a 12-month 'Success by Sesame' commitment, and the annual fee is explicitly non-refundable once paid - cancel in month two and you do not get the remaining ten months back
- ✗Medication costs are not included in the programme price, which Sesame states plainly but which means the real monthly outlay is the subscription plus the drug
- ✗Cash prices escalate steeply with dose. Zepbound more than doubles from $299 to $698 as you titrate to a maintenance dose, so the entry price is not the price you will end up paying
- ✗The Wegovy pen intro rate of $199 applies to new patients only and for two months, after which it is $349
- ✗Monthly subscribers are not refunded for months already paid, even if unused
- ✗Because pricing depends on insurance status, pharmacy and dose, there is no single figure you can plan around before signing up
- ✗This is a general healthcare marketplace, so the weight-loss programme sits alongside urgent care and prescription refills rather than being a dedicated speciality service
Signos
View full Signos review →Rating
7.8/10
Monthly Price
$127
Medications
continuous glucose monitoring
Pros
- ✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
- ✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
- ✓Two CGM sensors per month are included in every plan
- ✓HSA/FSA eligible, which matters at these prices
- ✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
- ✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
- ✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
- ✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
- ✓Stress and sleep tracking are built in alongside glucose
Cons
- ✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
- ✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
- ✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
- ✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
- ✗The results guarantee pays out in a free data audit, not money back
- ✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
- ✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm
Feature-by-feature comparison
| Feature | Sesame Care | Signos |
|---|---|---|
| Monthly Price | $59 | $127 |
| Rating | 8.7/10 | 7.8/10 |
| Medications | semaglutide, tirzepatide, orforglipron | continuous glucose monitoring |
| Insurance Accepted | Yes | No |
| Support Hours | Not published | In-app dietitian chat; hours not published |
| Live Chat | No | Available |
| Free Shipping | No | Yes |
| Shipping Speed | Filled at your pharmacy; not shipped by Sesame | Free shipping; six-month plans ship in three-month bundles |
| Mobile App | Available | Available |
| Dedicated Coach | Included | Included |
| Follow-up Frequency | Ongoing video visits, labs and messaging with a dedicated provider | Continuous glucose data with in-app dietitian support |
| Money-back Guarantee | Full refund if you cancel at least 3 hours before your first visit; annual fees are non-refundable once paid | 30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value) |
| Cancellation Policy | Self-cancel monthly or annual subscriptions any time, but past months and annual fees are not refunded | Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused |
Which should you choose?
Choose Sesame Care if you:
- →Want to save $68/month with a more affordable option
- →Prefer a higher-rated service (8.7/10 vs 7.8/10)
- →Want more medication options to choose from
- →Need insurance coverage for your treatment
- →Value: publishes cash prices dose by dose, which no other provider on this site does. zepbound kwikpen is $299/mo at 2.5mg, $398 at 5mg, $499 at 7.5mg and $698 at 10-15mg, so you can see exactly what titrating up will cost before you start
Choose Signos if you:
- →Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
Website previews
Sesame Care
Signos
Our recommendation
Sesame Care comes out ahead with a higher rating of 8.7/10. It also provides multiple medication options including both semaglutide and tirzepatide.
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