Shameless Care vs MadeMed
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Shameless Care vs MadeMed: Overview
Choosing between Shameless Care and MadeMed for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
Shameless Care offers both semaglutide and tirzepatide at $109/month with a rating of 8/10. MadeMed also provides both semaglutide and tirzepatide at $239/month with a 7.3/10 rating.
The price difference of $130/month is significant - Shameless Care is the more budget-friendly option, while MadeMed positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$130/mo
Rating Difference
0.7
Winner
Shameless Care
Best For
Budget
Shameless Care
View full Shameless Care review →Rating
8/10Better
Monthly Price
$109Cheaper
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
MadeMed
View full MadeMed review →Rating
7.3/10
Monthly Price
$239
Medications
semaglutidetirzepatide
Pros
- ✓The compounded disclaimer is explicit and sits on the product page itself, not in a distant footer
- ✓It directs patients to the FDA's adverse event reporting line (1-800-FDA-1088), which almost no competitor does
- ✓A real customer phone number is published rather than a contact form alone
- ✓Both semaglutide and tirzepatide are offered in injectable and oral forms
- ✓Quarterly billing at the starting dose is inexpensive - $239 per refill billed every three months for injectable semaglutide, and $399 for injectable tirzepatide (checked July 27, 2026)
- ✓The pricing footnote is honest about what it covers: 'Advertised pricing reflects the starting dosage'
- ✓Peptide and NAD+ lines are available alongside weight care
Cons
- ✗The monthly purchase option displays a price of '$0*/month'. On the primary buying path for the flagship product, the price simply does not render
- ✗Pricing is not flat across doses. The footnote states 'Actual price depends on the dosage prescribed by your provider', so the advertised figure applies only at the starting dose and rises as you titrate up - the opposite of the flat-price model most competitors offer, and a significant cost risk over a year
- ✗The '4.8/5' rating shown on product pages has no traceable source, and no Trustpilot profile exists for the domain
- ✗The homepage is effectively a navigation shell - it carries menus and a phone number but almost no content, pricing or explanation
- ✗Product pages are only reachable at bare paths such as /injectable-semaglutide; the more conventional /products/ and /weight-loss/ paths return empty shells
- ✗No refund or cancellation policy could be found beyond a 'Returns' link
- ✗No support hours are published, and there is no independent complaint record of any kind
- ✗Because the real cost depends on the dose you end up on, you cannot work out what a year of treatment will cost before signing up
Feature-by-feature comparison
| Feature | Shameless Care | MadeMed |
|---|---|---|
| Monthly Price | $109 | $239 |
| Rating | 8/10 | 7.3/10 |
| Medications | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline | semaglutide, tirzepatide |
| Insurance Accepted | No | No |
| Support Hours | Not published | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost | Not published |
| Mobile App | No | No |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | Board-certified physician assigned from start to finish; ongoing cadence not published | Board-certified physician review; follow-up frequency not published |
| Money-back Guarantee | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published | None published; only a 'Returns' link is provided |
| Cancellation Policy | No subscriptions - every purchase is one-off, so there is nothing to cancel | Not published; billing is monthly or quarterly per refill |
Which should you choose?
Choose Shameless Care if you:
- →Want to save $130/month with a more affordable option
- →Prefer a higher-rated service (8/10 vs 7.3/10)
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Choose MadeMed if you:
- →Value: the compounded disclaimer is explicit and sits on the product page itself, not in a distant footer
Website previews
Shameless Care
MadeMed
Our recommendation
Shameless Care comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.
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