Shameless Care vs MangoRx
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Shameless Care vs MangoRx: Overview
Choosing between Shameless Care and MangoRx for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
Shameless Care offers both semaglutide and tirzepatide at $109/month with a rating of 8/10. MangoRx also provides both semaglutide and tirzepatide at $299/month with a 7.4/10 rating.
The price difference of $190/month is significant - Shameless Care is the more budget-friendly option, while MangoRx positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$190/mo
Rating Difference
0.6
Winner
Shameless Care
Best For
Budget
Shameless Care
View full Shameless Care review →Rating
8/10Better
Monthly Price
$109Cheaper
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
MangoRx
View full MangoRx review →Rating
7.4/10
Monthly Price
$299
Medications
oral semaglutidetestosteronesildenafiltadalafil
Pros
- ✓Pricing is published without an intake and stated as locked in with no hidden fees: Slim oral semaglutide at $299/month and TRT starting at $99/month (checked July 28, 2026)
- ✓Provider visits and shipping are free on all orders, so there is no separate consultation fee stacked on top
- ✓The TRT program includes a comprehensive lab test and a personalized plan, with a full refund if you do not qualify - so the assessment carries no financial risk
- ✓The compounded-medication disclosure is thorough and correctly worded, including the point that clinical data from FDA-approved drugs may not transfer to compounded versions
- ✓It explicitly disclaims any relationship with Novo Nordisk or Eli Lilly rather than trading on their brand names
- ✓An orally dissolving tablet is a genuine convenience for people who will not inject, and the formulation adds vitamin B6, which the site says is intended to reduce nausea
- ✓Replied to 100% of negative Trustpilot reviews
- ✓A dedicated safety page, pharmacy disclaimer and telehealth consent are all published and dated
Cons
- ✗At $299/month, Slim is one of the more expensive semaglutide options we cover - and it is compounded. For comparison, the FDA-approved oral semaglutide listed elsewhere on this site sits at $149/month, so you would be paying roughly double for a preparation the FDA has not reviewed
- ✗There is no published bioavailability data for this tablet. Approved oral semaglutide relies on an absorption enhancer (SNAC) plus a strict fasting-and-water protocol precisely because semaglutide is a peptide that is poorly absorbed by mouth. Without that data, there is no way to know how much drug a compounded orally dissolving tablet actually delivers
- ✗The weight-loss figures associated with semaglutide - roughly 14.9% of body weight over 68 weeks in the STEP-1 trial - come from weekly subcutaneous injections of the branded drug, not from a compounded oral tablet. Do not assume the results transfer
- ✗The FDA declared the semaglutide shortage resolved in early 2025, after which compounders were required to stop producing what amounts to a copy of an approved drug. Providers still selling compounded semaglutide generally argue their formulation is materially different. It is a fair question to put to the provider before paying
- ✗The refund policy covers dispensing errors, cancellation before filling, and shipping damage reported within 7 days. It does not cover simply not getting on with the treatment
- ✗Only 15 Trustpilot reviews, and no BBB profile, so there is very little independent evidence either way
- ✗No corporate entity, address or phone number appears anywhere on the site - support is a single email address
- ✗This offer is not available in Alabama, Alaska, Arkansas, California, Kentucky, Louisiana, Michigan, Mississippi, North Dakota, South Carolina, South Dakota or Wyoming
- ✗The brand voice leans heavily on bravado - 'MAN. GO.', 'You badass' - which sits oddly against prescribing a GLP-1 and testosterone, where the tone you want is clinical caution
- ✗Semaglutide is not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, and is not for use in pregnancy. Pancreatitis and gallbladder disease are recognised risks
Feature-by-feature comparison
| Feature | Shameless Care | MangoRx |
|---|---|---|
| Monthly Price | $109 | $299 |
| Rating | 8/10 | 7.4/10 |
| Medications | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline | oral semaglutide, testosterone, sildenafil, tadalafil |
| Insurance Accepted | No | No |
| Support Hours | Not published | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost | Free discreet shipping on all orders; Slim ships monthly as a 30-day supply |
| Mobile App | No | No |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | Board-certified physician assigned from start to finish; ongoing cadence not published | Doctor-managed plans with lab-based adjustment on TRT; cadence not published |
| Money-back Guarantee | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published | Full refund on TRT if you do not qualify. Otherwise refunds are limited to dispensing errors, pre-fill cancellation, or shipping damage reported within 7 days |
| Cancellation Policy | No subscriptions - every purchase is one-off, so there is nothing to cancel | Monthly supply; cancellation before a prescription is filled is refundable, subject to the cancellation policy |
Which should you choose?
Choose Shameless Care if you:
- →Want to save $190/month with a more affordable option
- →Prefer a higher-rated service (8/10 vs 7.4/10)
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Choose MangoRx if you:
- →Value: pricing is published without an intake and stated as locked in with no hidden fees: slim oral semaglutide at $299/month and trt starting at $99/month (checked july 28, 2026)
Website previews
Shameless Care
MangoRx
Our recommendation
Shameless Care comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.
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