Shameless Care vs SkinnyRx
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Shameless Care vs SkinnyRx: Overview
Choosing between Shameless Care and SkinnyRx for GLP-1 weight loss medication? Both are highly-rated providers, but they differ in pricing, medication options, and service features.
Shameless Care offers both semaglutide and tirzepatide at $109/month with a rating of 8/10. SkinnyRx also provides both semaglutide and tirzepatide at $199/month with a 8/10 rating.
The price difference of $90/month is significant - Shameless Care is the more budget-friendly option, while SkinnyRx positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$90/mo
Rating Difference
0.0
Winner
Shameless Care
Best For
Budget
Shameless Care
View full Shameless Care review →Rating
8/10
Monthly Price
$109Cheaper
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
SkinnyRx
View full SkinnyRx review →Rating
8/10
Monthly Price
$199
Medications
semaglutidetirzepatide
Pros
- ✓Trustpilot rating of 4.8 across 5,272 reviews, an unusually strong independent signal for this category
- ✓Publishes a customer phone number, +1 (888) 979-9580, and a support email rather than hiding behind a portal
- ✓Full refund available any time before a licensed provider completes your prescription
- ✓Compounded injectable semaglutide from $199/month and tirzepatide, as tablets or injection, from $299/month, with microdose options (checked July 26, 2026)
- ✓Carefully separates compounded from brand-name in its own disclosures instead of implying the two are the same
- ✓Buy-now-pay-later through Affirm with the APR disclosed openly - the site gives a worked example of $800 split into 12 payments of $72.21 at 15% APR
- ✓A mobile app for meal plans, medication tracking and weight logging, plus unlimited provider messaging and free shipping
- ✓A substantial clinical content library covering practical issues like GLP-1s with levothyroxine, gallbladder pain and surgery timing
Cons
- ✗A '90-day money-back guarantee' is advertised in a banner on every page, but the site's own /money-back-guarantee link returns a 404 reading 'Page not found... Probably the link is broken'. We could not find the terms of that guarantee anywhere
- ✗The hero promises 'FDA-approved Wegovy, Foundayo and other GLP-1s', yet both the Wegovy Pill and Foundayo Pill are marked 'Unavailable' in the product list directly below
- ✗Pricing is at the higher end for compounded product: $199/month for semaglutide and $299/month for tirzepatide, where several rivals advertise under $150
- ✗'Lose up to 14.9% of your body weight' takes the figure from the STEP 1 trial of branded semaglutide and applies it to a compounded preparation that has not been trialled
- ✗The published refund window closes as soon as a provider completes your prescription, which can be the same day you sign up
- ✗A pop-up offers 'up to 43% off' without stating what plan or commitment unlocks that discount
- ✗No BBB profile or complaint history to cross-check the Trustpilot score against
- ✗No published support hours, so the phone line's availability is unknown
Feature-by-feature comparison
| Feature | Shameless Care | SkinnyRx |
|---|---|---|
| Monthly Price | $109 | $199 |
| Rating | 8/10 | 8/10 |
| Medications | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline | semaglutide, tirzepatide |
| Insurance Accepted | No | No |
| Support Hours | Not published | Not published |
| Live Chat | No | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost | Not published |
| Mobile App | No | Available |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | Board-certified physician assigned from start to finish; ongoing cadence not published | Unlimited provider messaging plus app-based tracking |
| Money-back Guarantee | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published | A 90-day money-back guarantee is advertised sitewide, but its terms page returns a 404; a full refund is available before a provider completes your prescription |
| Cancellation Policy | No subscriptions - every purchase is one-off, so there is nothing to cancel | Cancel anytime; full refund only before the prescription is completed by a provider |
Which should you choose?
Choose Shameless Care if you:
- →Want to save $90/month with a more affordable option
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Choose SkinnyRx if you:
- →Value: trustpilot rating of 4.8 across 5,272 reviews, an unusually strong independent signal for this category
Website previews
Shameless Care
SkinnyRx
Our recommendation
Shameless Care offers better value at $109/month while maintaining strong ratings. It also provides multiple medication options including both semaglutide and tirzepatide.
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