US Scripts MD vs Direct Meds
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
US Scripts MD vs Direct Meds: Overview
Choosing between US Scripts MD and Direct Meds for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
US Scripts MD offers both semaglutide and tirzepatide at $299/month with a rating of 7/10. Direct Meds also provides both semaglutide and tirzepatide at $297/month with a 8/10 rating.
With only a $2/month price difference, your choice will likely come down to features, support quality, and medication options.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$2/mo
Rating Difference
1.0
Winner
Direct Meds
Best For
Budget
US Scripts MD
View full US Scripts MD review →Rating
7/10
Monthly Price
$299
Medications
liraglutidesemaglutide
Pros
- ✓One of very few telehealth providers offering liraglutide, which suits people who cannot tolerate weekly dosing or who need a shorter-acting GLP-1
- ✓No price increase as your dose rises: "we keep our prices as low as possible and don't increase prices for high doses"
- ✓Free consultation, prescription, ongoing support and shipping are all bundled into the programme price
- ✓Free overnight, temperature-controlled shipping - genuine cold-chain handling rather than "ships fast"
- ✓An injection kit with spare syringes is included in every shipment
- ✓Anti-nausea medication is included with your first order, which is a thoughtful touch given how common GI side effects are
- ✓24/7 access to board-certified doctor support is advertised
- ✓You can cancel any time before your order ships, and there is a full refund if the providers decide you are not a fit for the programme
- ✓A $100 discount on the first month of weight-loss treatment
Cons
- ✗Expensive, and it gets more expensive: $299 for the first month, then $349/month thereafter
- ✗The alternative framing - "starter doses as low as $9.97/day" - is a per-day figure that works out to roughly $300 a month, which is not obviously cheap
- ✗Liraglutide is a daily injection and produced around 8% mean weight loss in the SCALE trial, meaningfully less than semaglutide or tirzepatide achieved in theirs
- ✗The medication is compounded and not FDA-approved
- ✗The refund guarantee only covers being declined - there is no satisfaction refund once you are on treatment
- ✗The dispensing pharmacy is not named
- ✗No insurance billing, and HSA/FSA acceptance is not stated
- ✗No published phone number
Direct Meds
View full Direct Meds review →Rating
8/10Better
Monthly Price
$297Cheaper
Medications
semaglutidetirzepatide
Pros
- ✓The compounding explanation is genuinely educational, citing USP 795 and USP 797 and identifying the pharmacy as a 503A facility rather than hand-waving about 'FDA-registered' status
- ✓Trustpilot rating of 4.6 from 12,750 reviews, a large and credible independent sample
- ✓The FAQ states flat monthly prices with no membership layered on: $297/month for semaglutide and $399/month for tirzepatide (checked July 27, 2026)
- ✓That price is stated to include the medication, doctor visits normally billed at $99 each, next-day FedEx or UPS shipping, and all injection supplies
- ✓Same price at every dose, so titrating up does not increase the bill
- ✓A full refund is given if your prescription is not approved
- ✓A published customer phone number, 888-696-7176, which most competitors do not offer
- ✓This offer is restricted in only one state, Arkansas
Cons
- ✗The headline price and the real price do not match. The landing page leads with 'Starting at $147' while the FAQ on the same site states 'For Semaglutide we charge $297/month. For Tirzepatide we charge $399/month' - roughly double
- ✗Discounts are advertised in three different sizes on one page: '$150 Off Today', 'Up to $200 OFF' and 'Get $150 OFF your prescription instantly', with no terms attached to any of them
- ✗The 'patient satisfaction guarantee' is undefined - 'If you are unhappy with your results, let us know and we'll make it right' commits to nothing specific
- ✗The landing page uses the same template as several other compounded GLP-1 funnels, down to the identical headline 'The proven way to lose 15% of your body weight fast!'
- ✗'We've been featured all over' appears with no named publications or links
- ✗The '15% of your body weight' figure comes from trials of the branded drugs, not from Direct Meds' compounded product or its own patients
- ✗No BBB profile could be found to set against the Trustpilot score
- ✗Support hours are not published, only the phone number and an email address
Feature-by-feature comparison
| Feature | US Scripts MD | Direct Meds |
|---|---|---|
| Monthly Price | $299 | $297 |
| Rating | 7/10 | 8/10 |
| Medications | liraglutide, semaglutide | semaglutide, tirzepatide |
| Insurance Accepted | No | No |
| Support Hours | Company advertises 24/7 access to partnering board-certified doctors | Not published |
| Live Chat | No | Available |
| Free Shipping | Yes | Yes |
| Shipping Speed | Free overnight shipping in temperature-controlled packaging | Next-day FedEx or UPS; arrives in 1-2 days |
| Mobile App | No | No |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | 24/7 access to partnering board-certified doctors for questions and support | 1:1 medical support with messaging and refills |
| Money-back Guarantee | Full refund if the medical providers determine you are not a fit for the programme | Full refund if your prescription is not approved; a vaguely worded satisfaction guarantee otherwise |
| Cancellation Policy | Cancel any time before your order ships; no contracts | Cancel anytime, no monthly membership |
Which should you choose?
Choose US Scripts MD if you:
- →Value: one of very few telehealth providers offering liraglutide, which suits people who cannot tolerate weekly dosing or who need a shorter-acting glp-1
Choose Direct Meds if you:
- →Want to save $2/month with a more affordable option
- →Prefer a higher-rated service (8/10 vs 7/10)
- →Value: the compounding explanation is genuinely educational, citing usp 795 and usp 797 and identifying the pharmacy as a 503a facility rather than hand-waving about 'fda-registered' status
Website previews
US Scripts MD
Direct Meds
Our recommendation
Direct Meds comes out ahead with a higher rating of 8/10. It also provides multiple medication options including both semaglutide and tirzepatide.
Get started with Direct MedsRelated comparisons
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