US Scripts MD vs Signos
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
US Scripts MD vs Signos: Overview
Choosing between US Scripts MD and Signos for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
US Scripts MD offers both semaglutide and tirzepatide at $299/month with a rating of 7/10. Signos offers continuous glucose monitoring at $127/month with a 7.8/10 rating.
The price difference of $172/month is significant - Signos is the more budget-friendly option, while US Scripts MD positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$172/mo
Rating Difference
0.8
Winner
Signos
Best For
Budget
US Scripts MD
View full US Scripts MD review →Rating
7/10
Monthly Price
$299
Medications
liraglutidesemaglutide
Pros
- ✓One of very few telehealth providers offering liraglutide, which suits people who cannot tolerate weekly dosing or who need a shorter-acting GLP-1
- ✓No price increase as your dose rises: "we keep our prices as low as possible and don't increase prices for high doses"
- ✓Free consultation, prescription, ongoing support and shipping are all bundled into the programme price
- ✓Free overnight, temperature-controlled shipping - genuine cold-chain handling rather than "ships fast"
- ✓An injection kit with spare syringes is included in every shipment
- ✓Anti-nausea medication is included with your first order, which is a thoughtful touch given how common GI side effects are
- ✓24/7 access to board-certified doctor support is advertised
- ✓You can cancel any time before your order ships, and there is a full refund if the providers decide you are not a fit for the programme
- ✓A $100 discount on the first month of weight-loss treatment
Cons
- ✗Expensive, and it gets more expensive: $299 for the first month, then $349/month thereafter
- ✗The alternative framing - "starter doses as low as $9.97/day" - is a per-day figure that works out to roughly $300 a month, which is not obviously cheap
- ✗Liraglutide is a daily injection and produced around 8% mean weight loss in the SCALE trial, meaningfully less than semaglutide or tirzepatide achieved in theirs
- ✗The medication is compounded and not FDA-approved
- ✗The refund guarantee only covers being declined - there is no satisfaction refund once you are on treatment
- ✗The dispensing pharmacy is not named
- ✗No insurance billing, and HSA/FSA acceptance is not stated
- ✗No published phone number
Signos
View full Signos review →Rating
7.8/10Better
Monthly Price
$127Cheaper
Medications
continuous glucose monitoring
Pros
- ✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
- ✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
- ✓Two CGM sensors per month are included in every plan
- ✓HSA/FSA eligible, which matters at these prices
- ✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
- ✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
- ✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
- ✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
- ✓Stress and sleep tracking are built in alongside glucose
Cons
- ✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
- ✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
- ✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
- ✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
- ✗The results guarantee pays out in a free data audit, not money back
- ✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
- ✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm
Feature-by-feature comparison
| Feature | US Scripts MD | Signos |
|---|---|---|
| Monthly Price | $299 | $127 |
| Rating | 7/10 | 7.8/10 |
| Medications | liraglutide, semaglutide | continuous glucose monitoring |
| Insurance Accepted | No | No |
| Support Hours | Company advertises 24/7 access to partnering board-certified doctors | In-app dietitian chat; hours not published |
| Live Chat | No | Available |
| Free Shipping | Yes | Yes |
| Shipping Speed | Free overnight shipping in temperature-controlled packaging | Free shipping; six-month plans ship in three-month bundles |
| Mobile App | No | Available |
| Dedicated Coach | Not included | Included |
| Follow-up Frequency | 24/7 access to partnering board-certified doctors for questions and support | Continuous glucose data with in-app dietitian support |
| Money-back Guarantee | Full refund if the medical providers determine you are not a fit for the programme | 30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value) |
| Cancellation Policy | Cancel any time before your order ships; no contracts | Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused |
Which should you choose?
Choose US Scripts MD if you:
- →Want more medication options to choose from
- →Value: one of very few telehealth providers offering liraglutide, which suits people who cannot tolerate weekly dosing or who need a shorter-acting glp-1
Choose Signos if you:
- →Want to save $172/month with a more affordable option
- →Prefer a higher-rated service (7.8/10 vs 7/10)
- →Want personalized coaching support included
- →Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
Website previews
US Scripts MD
Signos
Related comparisons
US Scripts MD vs CoreAge Rx
$299
★ 7
vs
$99
★ 9.6
US Scripts MD vs Zepbound
$299
★ 7
vs
$450
★ 9.3
US Scripts MD vs Mounjaro
$299
★ 7
vs
$1080
★ 9.2
US Scripts MD vs Wegovy Pill
$299
★ 7
vs
$149
★ 9.2
US Scripts MD vs Foundayo
$299
★ 7
vs
$149
★ 9.2
US Scripts MD vs Wegovy
$299
★ 7
vs
$349
★ 9.1
US Scripts MD vs NovoCare Pharmacy
$299
★ 7
vs
$149
★ 9
US Scripts MD vs Ozempic
$299
★ 7
vs
$349
★ 8.9
US Scripts MD vs Form Health
$299
★ 7
vs
$299
★ 8.8
US Scripts MD vs Henry Meds
$299
★ 7
vs
$179
★ 8.7
US Scripts MD vs Sesame Care
$299
★ 7
vs
$59
★ 8.7
US Scripts MD vs FuturHealth
$299
★ 7
vs
$225
★ 8.7
US Scripts MD vs Circle Medical
$299
★ 7
vs
$35
★ 8.7
US Scripts MD vs Ro
$299
★ 7
vs
$149
★ 8.6
US Scripts MD vs Midi Health
$299
★ 7
vs
$164
★ 8.6
US Scripts MD vs Noom Med
$299
★ 7
vs
$149
★ 8.6
US Scripts MD vs Precision Telemed
$299
★ 7
vs
$150
★ 8.6
US Scripts MD vs Hims
$299
★ 7
vs
$298
★ 8.5
US Scripts MD vs Calibrate
$299
★ 7
vs
$199
★ 8.5
US Scripts MD vs PlushCare
$299
★ 7
vs
$20
★ 8.5
Compare other providers
Compare GLP-1 Brands
vs