Winona vs Shameless Care
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Winona vs Shameless Care: Overview
Choosing between Winona and Shameless Care for GLP-1 weight loss medication? Both are highly-rated providers, but they differ in pricing, medication options, and service features.
Winona offers both semaglutide and tirzepatide at $89/month with a rating of 8.4/10. Shameless Care also provides both semaglutide and tirzepatide at $109/month with a 8/10 rating.
With only a $20/month price difference, your choice will likely come down to features, support quality, and medication options.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$20/mo
Rating Difference
0.4
Winner
Winona
Best For
Budget
Winona
View full Winona review →Rating
8.4/10Better
Monthly Price
$89Cheaper
Medications
bioidentical estradiolprogesteroneestriolDHEAsildenafilminoxidil
Pros
- ✓The full price list is published openly, with no intake required to see it: progesterone capsules from $39/mo, estrogen tablets from $54/mo, estrogen body cream (with progesterone) from $89/mo, vaginal estrogen cream from $89/mo and the estrogen patch from $149/mo (checked July 28, 2026)
- ✓Multiple delivery routes are offered - patch, body cream, vaginal cream, tablet and capsule - so treatment can be matched to preference rather than to whatever the company happens to stock
- ✓Winona owns its own 503A compounding pharmacies rather than outsourcing to a partner, which gives it direct control over formulation and consistency
- ✓Its pharmacy page explains the 503A/503B distinction correctly and states that 503A pharmacies are regulated by State Boards of Pharmacy, not the FDA - an accurate description that competitors routinely overstate
- ✓Roughly 8,000 Trustpilot reviews at 4.6, with 99% of negative reviews answered and a typical reply time under 24 hours
- ✓The rating advertised on site matches the rating on the public Trustpilot profile
- ✓The initial visit is free, so you can be assessed before paying for treatment
- ✓Editorial content carries numbered citations rather than unsourced assertions, and the site runs a public subreddit alongside a help centre and published phone number
- ✓HSA/FSA eligible, with a dedicated page explaining eligibility
- ✓Adjacent products are priced transparently too - DHEA from $27 per 3-month supply, sildenafil arousal cream at $79 per order, minoxidil hair serum at $150 per 3-month supply
Cons
- ✗Everything Winona dispenses is compounded in its own 503A pharmacies, which means it is not FDA-approved and has not been evaluated by the FDA for safety, efficacy or quality. The site explains 503A status clearly but does not foreground the 'not FDA-approved' consequence as plainly
- ✗Pharmaceutical products cannot be returned, per the terms - so once a prescription ships, you own it
- ✗The terms carry a mandatory arbitration clause on an individual basis with a class-action waiver, set out in capitals at the top of the document
- ✗Every headline price is a 'from' figure, so the actual monthly cost depends on the dose your clinician prescribes and is not knowable before the consultation
- ✗The hormone therapy explainer describes HRT as 'scientifically proven to be the safest, most effective treatment' for menopause symptoms. It is cited, but that is a strong framing for a therapy whose risk profile still depends heavily on age, time since menopause and personal history
- ✗Trustpilot notes Winona invites customers to review, which tends to lift scores relative to organic-only profiles, and that it may use AI-assisted replies
- ✗Systemic estrogen is not appropriate for everyone - women with a history of breast or endometrial cancer, unexplained vaginal bleeding, blood clots, stroke or liver disease should not start it without specialist input
- ✗Compounded hormone therapy in general lacks the long-term outcome data that exists for FDA-approved products, so the evidence cited for HRT as a class does not transfer automatically to these specific preparations
Shameless Care
View full Shameless Care review →Rating
8/10
Monthly Price
$109
Medications
sildenafiltadalafilapomorphinebremelanotideoxytocinvalacyclovirdoxycycline
Pros
- ✓The whole price list sits on the homepage with no intake required: 14-panel STI testing $279, ED from $109, DoxyPEP from $99, valacyclovir from $109, and UTI, bacterial vaginosis and yeast infection treatment at $63 each (checked July 28, 2026)
- ✓There are no subscriptions at all. 'No subscriptions. No recurring charges. Ever.' is stated on every product page, which removes the auto-renewal trap that affects most of this category
- ✓Every price is all-in: physician consult, prescription, medication and overnight or 2-day shipping are included with no separate consultation fee
- ✓The compounding disclosure is precise and correct, and appears on each compounded product rather than buried in a footer
- ✓Exact doses and beyond-use dates are published for compounded products - genuinely rare, and it lets you see how long a preparation is actually good for
- ✓The ED range clearly separates FDA-approved generic sildenafil and tadalafil from the compounded Duo and Trio blends, so you can choose a plain approved medicine if you prefer
- ✓The STI panel is clinically thoughtful. It includes oral and anal swabs and explains why: chlamydia and gonorrhoea can infect the throat or rectum, and urine-and-blood-only panels miss those infections entirely. Most direct-to-consumer STI kits do not collect those sites
- ✓Testing is physician-ordered with a named board-certified physician assigned, and results come 2-3 days after the lab receives your kit
- ✓Its own editorial is unusually candid about the industry it operates in, including a piece on 'The Uncomfortable Truth About Online ED Sales'
- ✓Compounded medication is made to order within three business days and shipped in insulated packaging at no extra cost
Cons
- ✗Prices are high relative to alternatives. DoxyPEP starts at $99 here against $22 at Wisp, and UTI treatment is $63 against Wisp's cheaper generics. You are paying a premium for the all-in, no-subscription model
- ✗The Trio blend stacks two PDE5 inhibitors - sildenafil and tadalafil - and adds apomorphine. Duo stacks the two PDE5 inhibitors. No FDA-approved product combines two PDE5 inhibitors, and doubling the same mechanism compounds the blood-pressure-lowering effect without established added benefit
- ✗Shameless Desire combines tadalafil with apomorphine and oxytocin. Apomorphine independently lowers blood pressure and causes nausea, so the combined hypotensive risk deserves a direct conversation with the prescriber
- ✗Bremelanotide is FDA-approved only as Vyleesi, an autoinjector for premenopausal women with hypoactive sexual desire disorder. Selling it as a compounded nasal spray for both men and women is a different route of administration and an off-label use
- ✗Oxytocin at 100 IU sublingually for desire has essentially no controlled trial evidence supporting it
- ✗The bremelanotide nasal spray carries a 30-day beyond-use date, so a $235 purchase has to be used quickly or wasted
- ✗The advertised '4.9-Star Rating' and '10,000+ patients served' could not be verified against any independent source
- ✗Not available in all 50 states - the site states 49
- ✗Anyone taking nitrates or riociguat must not use the PDE5-containing products, and the apomorphine-containing ones interact seriously with 5-HT3 anti-emetics such as ondansetron
Feature-by-feature comparison
| Feature | Winona | Shameless Care |
|---|---|---|
| Monthly Price | $89 | $109 |
| Rating | 8.4/10 | 8/10 |
| Medications | bioidentical estradiol, progesterone, estriol, DHEA, sildenafil, minoxidil | sildenafil, tadalafil, apomorphine, bremelanotide, oxytocin, valacyclovir, doxycycline |
| Insurance Accepted | No | No |
| Support Hours | Help centre and chat available; hours not published | Not published |
| Live Chat | Available | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Shipped to your door after clinician review; free shipping included | Made to order within three business days, then overnight or UPS 2nd Day Air in insulated packaging at no extra cost |
| Mobile App | No | No |
| Dedicated Coach | Not included | Not included |
| Follow-up Frequency | Ongoing clinician access through the patient portal; cadence not published | Board-certified physician assigned from start to finish; ongoing cadence not published |
| Money-back Guarantee | None published; pharmaceutical products cannot be returned. A separate cancellation and refund policy governs subscriptions | Advertises a '100% Service Guarantee' and '100% Satisfaction'; specific terms not published |
| Cancellation Policy | Subscriptions can be cancelled from your account; a separate cancellation policy governs when it takes effect | No subscriptions - every purchase is one-off, so there is nothing to cancel |
Which should you choose?
Choose Winona if you:
- →Want to save $20/month with a more affordable option
- →Prefer a higher-rated service (8.4/10 vs 8/10)
- →Value: the full price list is published openly, with no intake required to see it: progesterone capsules from $39/mo, estrogen tablets from $54/mo, estrogen body cream (with progesterone) from $89/mo, vaginal estrogen cream from $89/mo and the estrogen patch from $149/mo (checked july 28, 2026)
Choose Shameless Care if you:
- →Want more medication options to choose from
- →Value: the whole price list sits on the homepage with no intake required: 14-panel sti testing $279, ed from $109, doxypep from $99, valacyclovir from $109, and uti, bacterial vaginosis and yeast infection treatment at $63 each (checked july 28, 2026)
Website previews
Winona
Shameless Care
Our recommendation
Winona comes out ahead with a higher rating of 8.4/10. It also provides multiple medication options including both semaglutide and tirzepatide.
Get started with WinonaRelated comparisons
Winona vs CoreAge Rx
$89
★ 8.4
vs
$99
★ 9.6
Winona vs Zepbound
$89
★ 8.4
vs
$450
★ 9.3
Winona vs Mounjaro
$89
★ 8.4
vs
$1080
★ 9.2
Winona vs Wegovy Pill
$89
★ 8.4
vs
$149
★ 9.2
Winona vs Foundayo
$89
★ 8.4
vs
$149
★ 9.2
Winona vs Wegovy
$89
★ 8.4
vs
$349
★ 9.1
Winona vs NovoCare Pharmacy
$89
★ 8.4
vs
$149
★ 9
Winona vs Ozempic
$89
★ 8.4
vs
$349
★ 8.9
Winona vs Form Health
$89
★ 8.4
vs
$299
★ 8.8
Winona vs Henry Meds
$89
★ 8.4
vs
$179
★ 8.7
Winona vs Sesame Care
$89
★ 8.4
vs
$59
★ 8.7
Winona vs FuturHealth
$89
★ 8.4
vs
$225
★ 8.7
Winona vs Circle Medical
$89
★ 8.4
vs
$35
★ 8.7
Winona vs Ro
$89
★ 8.4
vs
$149
★ 8.6
Winona vs Midi Health
$89
★ 8.4
vs
$164
★ 8.6
Winona vs Noom Med
$89
★ 8.4
vs
$149
★ 8.6
Winona vs Precision Telemed
$89
★ 8.4
vs
$150
★ 8.6
Winona vs Hims
$89
★ 8.4
vs
$298
★ 8.5
Winona vs Calibrate
$89
★ 8.4
vs
$199
★ 8.5
Winona vs PlushCare
$89
★ 8.4
vs
$20
★ 8.5
Compare other providers
Compare GLP-1 Brands
vs