← All providers

Signos vs Calibrate

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Signos vs Calibrate: Overview

Choosing between Signos and Calibrate for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Signos focuses on continuous glucose monitoring at $127/month with a rating of 7.8/10. Calibrate also provides both semaglutide and tirzepatide at $199/month with a 8.5/10 rating.

The price difference of $72/month is significant - Signos is the more budget-friendly option, while Calibrate positions itself as a premium service.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$72/mo

Rating Difference

0.7

Winner

Calibrate

Best For

Quality

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Calibrate

View full Calibrate review →

Rating

8.5/10Better

Monthly Price

$199

Medications

semaglutidetirzepatide

Pros

✓Prescribes only brand-name, FDA-approved GLP-1s - Zepbound, Mounjaro, Wegovy, Ozempic and Foundayo - with no compounded products
✓Publishes a genuine long-term outcome: 20% weight loss achieved at three years, which is a far longer follow-up than the 68-72 week trial data most providers cite
✓Includes 1:1 video coaching and lifestyle support rather than shipping medication and leaving you to it
✓Dedicated insurance navigation support to get the medication covered, instead of assuming cash-pay
✓Available either directly as an individual or through a participating employer
✓Starting price is published openly at $199/month (checked July 28, 2026)

Cons

✗At $199/month for the programme, this is a coaching-led service and the medication cost is separate - what you pay in total depends on your insurance
✗The $199 figure is a 'starting at' price
✗Because it only prescribes brand-name GLP-1s, cost without insurance coverage will be substantially higher than compounded alternatives
✗The 4.5 rating from 1,618 reviews is displayed on Calibrate's own site rather than an independent platform
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy

Choose Calibrate

Feature-by-feature comparison

Feature	Signos	Calibrate
Monthly Price	$127	$199
Rating	7.8/10	8.5/10
Medications	continuous glucose monitoring	semaglutide, tirzepatide
Insurance Accepted	No	Yes
Support Hours	In-app dietitian chat; hours not published	Not published
Live Chat	Available	No
Free Shipping	Yes	No
Shipping Speed	Free shipping; six-month plans ship in three-month bundles	Prescriptions filled through your pharmacy
Mobile App	Available	Available
Dedicated Coach	Included	Included
Follow-up Frequency	Continuous glucose data with in-app dietitian support	1:1 video coaching throughout the Metabolic Reset programme
Money-back Guarantee	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)	None published
Cancellation Policy	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused	Programme based; terms not published

Which should you choose?

Choose Signos if you:

→Want to save $72/month with a more affordable option
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Choose Calibrate if you:

→Prefer a higher-rated service (8.5/10 vs 7.8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Value: prescribes only brand-name, fda-approved glp-1s - zepbound, mounjaro, wegovy, ozempic and foundayo - with no compounded products

Get started with Calibrate

Website previews

Signos

Signos website

Calibrate

Calibrate website

Our recommendation

Calibrate comes out ahead with a higher rating of 8.5/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Calibrate

Related comparisons

Signos vs CoreAge Rx

Signos vs Zepbound

Signos vs Mounjaro

Signos vs Wegovy Pill

Signos vs Foundayo

Signos vs Wegovy

Signos vs NovoCare Pharmacy

Signos vs Ozempic

Signos vs Form Health

Signos vs Henry Meds

Signos vs Sesame Care

Signos vs FuturHealth

Signos vs Circle Medical

Signos vs Ro

Signos vs Midi Health

Signos vs Noom Med

Signos vs Precision Telemed

Signos vs Hims

Signos vs PlushCare

Signos vs LifeMD

Compare other providers

Compare GLP-1 Brands

First Brand

vs

Second Brand