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Signos vs Midi Health

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Signos vs Midi Health: Overview

Choosing between Signos and Midi Health for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Signos focuses on continuous glucose monitoring at $127/month with a rating of 7.8/10. Midi Health also provides both semaglutide and tirzepatide at $164/month with a 8.6/10 rating.

With only a $37/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$37/mo

Rating Difference

0.8

Winner

Midi Health

Best For

Quality

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Midi Health

View full Midi Health review →

Rating

8.6/10Better

Monthly Price

$164

Medications

compounded GLP-1compounded GLP-1/GIPbrand-name GLP-1s

Pros

✓The GLP-1 pricing page is the most transparent we have seen anywhere in this category: a dose-by-dose table for four different products, with shipping and supplies included in every figure (checked July 28, 2026)
✓Compounded GLP-1 injectable runs $165.90 for the lowest doses, $270.90 in the mid range and $355.00 at the top; the dual-action GLP-1/GIP injectable runs $210.00 to $434.00, all for a 4-week supply
✓Sublingual options are offered as well, from $164.00 for GLP-1 and $209.00 for dual-action GLP-1/GIP, for people who will not inject
✓Its partner compounding pharmacies are 503B-accredited. 503B outsourcing facilities register with the FDA, are subject to current good manufacturing practice requirements and are FDA-inspected - a materially higher standard than the 503A pharmacies most competitors use
✓There is no membership fee. You pay for care and medication only
✓Visits are insurance-covered for qualifying patients, and HSA/FSA funds can be used for copays and services
✓Midi will also prescribe brand-name GLP-1s sent to a pharmacy of your choice, so you are not locked into compounded product if you would rather have the approved drug
✓The efficacy claim is the best-sourced in this category. Midi reports patients lost an average of 16 lbs after six or more months, and footnotes it to a retrospective analysis of 6,958 patients who completed two or more weight management visits between 1 May 2025 and 30 April 2026, while stating plainly that weight data were self-reported and results are not guaranteed
✓Care is genuinely whole-person for midlife women - perimenopause, menopause, weight, mood and memory, sexual wellness, hair and skin, sleep, and cancer survivorship - with lab orders and lifestyle support included where appropriate
✓Available in all 50 states

Cons

✗The compounded products are still not FDA-approved. 503B accreditation raises the manufacturing standard considerably but does not mean the FDA has reviewed these preparations for safety or efficacy
✗Midi never names the active drug anywhere in its pricing. Everything is labelled 'GLP-1' or 'GLP-1/GIP'. The dose ladders shown - 0.25 through 2.5 mg, and 2.5 through 15 mg - match the standard semaglutide and tirzepatide titrations exactly, but you should confirm with the clinician what you are actually being prescribed
✗Microdosing is offered from $34 a week for eligible patients. Microdosing is not an evidence-based protocol - the trials behind these drugs used full therapeutic doses, and the 16 lb outcome figure covers patients on 'a range of treatments', not microdosing specifically
✗Medicaid and Medi-Cal patients cannot be treated at all, even if they offer to pay cash
✗Medicare does not cover Midi, and beneficiaries cannot submit claims for visits, medications or associated services
✗Prices rise steeply as you titrate up. Injectable GLP-1 more than doubles from $165.90 to $355.00, and the dual-action sublingual runs from $209.00 to $460.00, so the entry price is not what you will pay long term
✗The 16 lb average comes from self-reported weights in a retrospective chart review with no control group - well documented, but not a controlled trial
✗GLP-1 medications are not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or during pregnancy. Pancreatitis and gallbladder disease are recognised risks

Choose Midi Health

Feature-by-feature comparison

Feature	Signos	Midi Health
Monthly Price	$127	$164
Rating	7.8/10	8.6/10
Medications	continuous glucose monitoring	compounded GLP-1, compounded GLP-1/GIP, brand-name GLP-1s
Insurance Accepted	No	Yes
Support Hours	In-app dietitian chat; hours not published	Not published
Live Chat	Available	No
Free Shipping	Yes	Yes
Shipping Speed	Free shipping; six-month plans ship in three-month bundles	Discreet shipping included in every quoted medication price
Mobile App	Available	No
Dedicated Coach	Included	Not included
Follow-up Frequency	Continuous glucose data with in-app dietitian support	Continued care visits with the same clinician, covered by insurance for qualifying patients
Money-back Guarantee	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)	None published
Cancellation Policy	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused	No membership fee and no subscription lock-in; you pay for care and medication only

Which should you choose?

Choose Signos if you:

→Want to save $37/month with a more affordable option
→Want personalized coaching support included
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Choose Midi Health if you:

→Prefer a higher-rated service (8.6/10 vs 7.8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Value: the glp-1 pricing page is the most transparent we have seen anywhere in this category: a dose-by-dose table for four different products, with shipping and supplies included in every figure (checked july 28, 2026)

Get started with Midi Health

Website previews

Signos

Signos website

Midi Health

Midi Health website

Our recommendation

Midi Health comes out ahead with a higher rating of 8.6/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Midi Health

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