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Signos vs Ro

Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey

Signos vs Ro: Overview

Choosing between Signos and Ro for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.

Signos focuses on continuous glucose monitoring at $127/month with a rating of 7.8/10. Ro also provides both semaglutide and tirzepatide at $149/month with a 8.6/10 rating.

With only a $22/month price difference, your choice will likely come down to features, support quality, and medication options.

Our recommended brand

After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.

Visit CoreAge Rx →Read full review

At a glance

Price Difference

$22/mo

Rating Difference

0.8

Winner

Ro

Best For

Quality

Signos

View full Signos review →

Rating

7.8/10

Monthly Price

$127Cheaper

Medications

continuous glucose monitoring

Pros

✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
✓Two CGM sensors per month are included in every plan
✓HSA/FSA eligible, which matters at these prices
✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
✓Stress and sleep tracking are built in alongside glucose

Cons

✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
✗The results guarantee pays out in a free data audit, not money back
✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm

Ro

View full Ro review →

Rating

8.6/10Better

Monthly Price

$149

Medications

semaglutidetirzepatide

Pros

✓Prescribes FDA-approved, brand-name GLP-1s - Zepbound, Wegovy pen and pill, Ozempic, Saxenda and the new Foundayo pill - rather than compounded copies
✓Real insurance support: a dedicated team handles prior authorizations and appeals, and there is a free GLP-1 insurance checker you can run before paying anything
✓Publishes exact cash-pay prices for the Zepbound KwikPen: $299/mo at 2.5 mg, $399/mo at 5 mg and $449/mo at 7.5-15 mg with the manufacturer offer (checked July 26, 2026)
✓Membership is $39 for the first month, and as low as $74/mo if you prepay for a year
✓Long-established: trading since 2017, BBB accredited since 2018, and one of the largest telehealth platforms in the US
✓Prescriptions are typically filled and shipped within 1-4 days
✓Cash-pay Zepbound single-dose vials are available if you want to skip the insurance process entirely
✓Ongoing provider messaging, check-ins and progress tracking are included in the membership fee

Cons

✗The membership fee does not include your medication. At $149/mo month-to-month plus $449/mo for a maintenance dose of Zepbound, the realistic all-in cost is roughly $520-600 a month
✗The discounted $449 refill price depends on completing a check-in within 45 days of your last delivery. Miss that window and the price jumps to $499 for 7.5 mg, or $699 for the 10, 12.5 and 15 mg doses
✗All sales are final. Ro states it cannot issue refunds or accept returns on prescription products, except where it has made an error filling your prescription
✗The headline $74/mo membership rate requires prepaying a full year upfront
✗BBB lists 619 complaints, and Trustpilot sits at 3.8 from 4,796 reviews, with cancellation and billing the dominant negative themes
✗No customer phone number or support email is published on the site; support runs through your account
✗Because the medication price depends on your insurance, what you will actually pay each month cannot be known until after you have signed up and been assessed
✗The homepage claim 'Lose 20% body weight on average with Zepbound' comes from the manufacturer's trial of the branded drug, not from Ro's own patients

Feature-by-feature comparison

Feature	Signos	Ro
Monthly Price	$127	$149
Rating	7.8/10	8.6/10
Medications	continuous glucose monitoring	semaglutide, tirzepatide
Insurance Accepted	No	Yes
Support Hours	In-app dietitian chat; hours not published	On-demand provider messaging (hours not published)
Live Chat	Available	No
Free Shipping	Yes	Yes
Shipping Speed	Free shipping; six-month plans ship in three-month bundles	Typically filled and shipped within 1-4 days
Mobile App	Available	Available
Dedicated Coach	Included	Included
Follow-up Frequency	Continuous glucose data with in-app dietitian support	Ongoing check-ins plus on-demand provider messaging
Money-back Guarantee	30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value)	None - Ro states all sales of prescription products are final, except where it filled your prescription in error
Cancellation Policy	Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused	Cancel the membership before your next billing date; charges already processed are not refunded

Which should you choose?

Choose Signos if you:

→Want to save $22/month with a more affordable option
→Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription

Get started with Signos

Choose Ro if you:

→Prefer a higher-rated service (8.6/10 vs 7.8/10)
→Want more medication options to choose from
→Need insurance coverage for your treatment
→Value: prescribes fda-approved, brand-name glp-1s - zepbound, wegovy pen and pill, ozempic, saxenda and the new foundayo pill - rather than compounded copies

Get started with Ro

Website previews

Signos

Signos website

Ro

Ro website

Our recommendation

Ro comes out ahead with a higher rating of 8.6/10. It also provides multiple medication options including both semaglutide and tirzepatide.

Get started with Ro

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