Signos vs MangoRx
Compare pricing, features, and medications to find the best GLP-1 provider for your weight loss journey
Signos vs MangoRx: Overview
Choosing between Signos and MangoRx for GLP-1 weight loss medication? Both are popular providers, but they differ in pricing, medication options, and service features.
Signos focuses on continuous glucose monitoring at $127/month with a rating of 7.8/10. MangoRx also provides both semaglutide and tirzepatide at $299/month with a 7.4/10 rating.
The price difference of $172/month is significant - Signos is the more budget-friendly option, while MangoRx positions itself as a premium service.
Our recommended brand
After reviewing all 148 providers on this platform, we've identified CoreAge Rx as offering the most transparent pricing model. At just $99/month — the same price every month, every dose — there are no surprise charges or hidden fees. Combined with exceptional service quality, personalized support, and access to both semaglutide and tirzepatide, it represents the best value without compromising on care.
At a glance
Price Difference
$172/mo
Rating Difference
0.4
Winner
Signos
Best For
Budget
Signos
View full Signos review →Rating
7.8/10Better
Monthly Price
$127Cheaper
Medications
continuous glucose monitoring
Pros
- ✓A genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
- ✓Published plan pricing: $127/month on the longest plan, $150/month on the mid plan and $225/month on the shortest, each discounted from a higher list price
- ✓Two CGM sensors per month are included in every plan
- ✓HSA/FSA eligible, which matters at these prices
- ✓Registered dietitian support is included, with in-app chat and the option of a face-to-face session
- ✓A 30-day results guarantee: if you do not learn something new about how your body loses weight, a senior Signos coach audits your data free, described as a $250 value
- ✓One membership covers the sensors, the app, the coaching and the behaviour-change programme instead of stacking separate subscriptions
- ✓It pairs sensibly with a GLP-1 rather than competing with one, and the company states medication costs are included in the Signos programme where applicable
- ✓Stress and sleep tracking are built in alongside glucose
Cons
- ✗This is not a GLP-1 prescribing service in the way the rest of this site is. If you came here for a semaglutide prescription, Signos is a different kind of product
- ✗The cheapest per-month rate requires the longest commitment, and six-month plans ship in three-month bundles
- ✗CGM-guided eating for weight loss in people without diabetes has far weaker evidence behind it than GLP-1 medication
- ✗HSA/FSA eligibility is qualified - "Possibly, but it depends on your HSA/FSA provider" - and Signos states it is not responsible for reimbursement, with the cancellation policy still applying if your provider refuses
- ✗The results guarantee pays out in a free data audit, not money back
- ✗Outcome claims reflect individual Signos patient experiences rather than published clinical studies, which the company discloses
- ✗Not suitable if you are on insulin without speaking to your own clinician first, which the signup flow asks you to confirm
MangoRx
View full MangoRx review →Rating
7.4/10
Monthly Price
$299
Medications
oral semaglutidetestosteronesildenafiltadalafil
Pros
- ✓Pricing is published without an intake and stated as locked in with no hidden fees: Slim oral semaglutide at $299/month and TRT starting at $99/month (checked July 28, 2026)
- ✓Provider visits and shipping are free on all orders, so there is no separate consultation fee stacked on top
- ✓The TRT program includes a comprehensive lab test and a personalized plan, with a full refund if you do not qualify - so the assessment carries no financial risk
- ✓The compounded-medication disclosure is thorough and correctly worded, including the point that clinical data from FDA-approved drugs may not transfer to compounded versions
- ✓It explicitly disclaims any relationship with Novo Nordisk or Eli Lilly rather than trading on their brand names
- ✓An orally dissolving tablet is a genuine convenience for people who will not inject, and the formulation adds vitamin B6, which the site says is intended to reduce nausea
- ✓Replied to 100% of negative Trustpilot reviews
- ✓A dedicated safety page, pharmacy disclaimer and telehealth consent are all published and dated
Cons
- ✗At $299/month, Slim is one of the more expensive semaglutide options we cover - and it is compounded. For comparison, the FDA-approved oral semaglutide listed elsewhere on this site sits at $149/month, so you would be paying roughly double for a preparation the FDA has not reviewed
- ✗There is no published bioavailability data for this tablet. Approved oral semaglutide relies on an absorption enhancer (SNAC) plus a strict fasting-and-water protocol precisely because semaglutide is a peptide that is poorly absorbed by mouth. Without that data, there is no way to know how much drug a compounded orally dissolving tablet actually delivers
- ✗The weight-loss figures associated with semaglutide - roughly 14.9% of body weight over 68 weeks in the STEP-1 trial - come from weekly subcutaneous injections of the branded drug, not from a compounded oral tablet. Do not assume the results transfer
- ✗The FDA declared the semaglutide shortage resolved in early 2025, after which compounders were required to stop producing what amounts to a copy of an approved drug. Providers still selling compounded semaglutide generally argue their formulation is materially different. It is a fair question to put to the provider before paying
- ✗The refund policy covers dispensing errors, cancellation before filling, and shipping damage reported within 7 days. It does not cover simply not getting on with the treatment
- ✗Only 15 Trustpilot reviews, and no BBB profile, so there is very little independent evidence either way
- ✗No corporate entity, address or phone number appears anywhere on the site - support is a single email address
- ✗This offer is not available in Alabama, Alaska, Arkansas, California, Kentucky, Louisiana, Michigan, Mississippi, North Dakota, South Carolina, South Dakota or Wyoming
- ✗The brand voice leans heavily on bravado - 'MAN. GO.', 'You badass' - which sits oddly against prescribing a GLP-1 and testosterone, where the tone you want is clinical caution
- ✗Semaglutide is not suitable for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, and is not for use in pregnancy. Pancreatitis and gallbladder disease are recognised risks
Feature-by-feature comparison
| Feature | Signos | MangoRx |
|---|---|---|
| Monthly Price | $127 | $299 |
| Rating | 7.8/10 | 7.4/10 |
| Medications | continuous glucose monitoring | oral semaglutide, testosterone, sildenafil, tadalafil |
| Insurance Accepted | No | No |
| Support Hours | In-app dietitian chat; hours not published | Not published |
| Live Chat | Available | No |
| Free Shipping | Yes | Yes |
| Shipping Speed | Free shipping; six-month plans ship in three-month bundles | Free discreet shipping on all orders; Slim ships monthly as a 30-day supply |
| Mobile App | Available | No |
| Dedicated Coach | Included | Not included |
| Follow-up Frequency | Continuous glucose data with in-app dietitian support | Doctor-managed plans with lab-based adjustment on TRT; cadence not published |
| Money-back Guarantee | 30-day results guarantee - if you do not learn something new about how your body loses weight, a senior coach audits your data free (stated as a $250 value) | Full refund on TRT if you do not qualify. Otherwise refunds are limited to dispensing errors, pre-fill cancellation, or shipping damage reported within 7 days |
| Cancellation Policy | Subscription plans; cancellation terms apply even if HSA/FSA reimbursement is refused | Monthly supply; cancellation before a prescription is filled is refundable, subject to the cancellation policy |
Which should you choose?
Choose Signos if you:
- →Want to save $172/month with a more affordable option
- →Prefer a higher-rated service (7.8/10 vs 7.4/10)
- →Want personalized coaching support included
- →Value: a genuinely different approach: a continuous glucose monitor plus an app that tells you how your own body responds to specific foods, rather than a prescription subscription
Choose MangoRx if you:
- →Want more medication options to choose from
- →Value: pricing is published without an intake and stated as locked in with no hidden fees: slim oral semaglutide at $299/month and trt starting at $99/month (checked july 28, 2026)
Website previews
Signos
MangoRx
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